GLYcoDiag
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GLYcoDiag is a research and development company specialized in glycosciences which provides services and products for the fields of health (biomarkers, therapeutic recombinant glycoproteins, vaccines), cosmetics (active ingredients, design and mechanisms of “glyco-actives”) and environment (biofilms, waste water).
Since 2015, GLYcoDiag develop its own range of reagents and kits for research uses:
Natural and recombinant lectins
Neoglycoproteins and neoglycoclusters
LEctPROFILE® gels, CarbPROFILE gels LEctPROFILE® kits (lectin based kits intended for ligands screening / comparison / detection) Website : www.glycodiag.com
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![Galanthus nivalis Lectin (GNL/GNA)](https://www.clinisciences.com/en/upload/thumbs/galanthus-nivalis-snowdrop-lectin-ss7kap-c0b3f2.jpg)
Galanthus nivalis Lectin (GNL/GNA)
Galanthus nivalis lectin or agglutinin (GNL/GNA) is isolated from snowdrop bulbs. GNL consists of four identical subunits with a molecular weight of 50,000 and an isoelectric point between pH 3.5 and pH 4.0. Galanthus nivalis lectin, unlike most mannose-specific lectins, is not a metalloprotein and does not require Ca++or Mn++ for binding.
This lectin is known to agglutinate rabbit erythrocytes but not human erythrocytes. GNL contains little to no carbohydrate and specifically binds to murine IgM immunoglobin and human beta2-macroglobulin, but not to alpha-linked glucose (unlike majority of mannose-binding lectins). Structures containing (beta-1,3) mannose residues are preferred for binding and elutes with the sugar Mannose. GNL is useful for HIV research, applicable for blood cell agglutination studies, and has set a model system to help understand the molecular basis of how proteins recognize carbohydrates.
GLN is used for blood cell agglutination studies, HIV research, virus isolation, mouse IgM isolation.
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