GLYcoDiag
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GLYcoDiag is a research and development company specialized in glycosciences which provides services and products for the fields of health (biomarkers, therapeutic recombinant glycoproteins, vaccines), cosmetics (active ingredients, design and mechanisms of “glyco-actives”) and environment (biofilms, waste water).
Since 2015, GLYcoDiag develop its own range of reagents and kits for research uses:
Natural and recombinant lectins
Neoglycoproteins and neoglycoclusters
LEctPROFILE® gels, CarbPROFILE gels LEctPROFILE® kits (lectin based kits intended for ligands screening / comparison / detection) Website : www.glycodiag.com
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![Sambucus nigra Lectin (SNA/EBL I+II)](https://www.clinisciences.com/en/upload/thumbs/sambucus-nigra-elderberry-lectin-ukeftc-17c6fd.jpg)
Sambucus nigra Lectin (SNA/EBL I+II)
Sambucus nigra lectin (EBL I+II, also known as SNA) is isolated from elderberry bark. This lectin has a molecular weight of 140 kDa and is composed of two ricin-related lectins. EBL I+II is a tetrameric glycoprotein with a recognition of the Neu5Ac(alpha2-6)Gal or GalNAc linkage in glycoconjugates.
EBL I+II is not blood group specific but it does agglutinate type A erythrocytes more strongly than either B or O cells. Trypsin treated erythrocytes react better than untreated cells. Neuraminidase treated erythrocytes react with this lectin due to the presence of terminal galactose resides.
EBL I is composed of an A-chain with enzymatic activity and a B-chain with carbohydrate-binding activity. EBL II consists only of carbohydrate-binding B-chains. EBL I+II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems independent from the catalytic activity of the A-chain, but depends on the carbohydrate binding B-chain.
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