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bioWORLD is a global leader in manufacturing and supplying a wide range of products for life science research. With over 25 years of experience, they have focused on providing quality products and excellent customer service. Their diverse customer base includes hospitals, public health institutions, commercial laboratories, biotechnology companies, pharmaceutical firms, universities, and research institutions. Website : www.bio-world.com
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Galanthus nivalis Lectin (GNL/GNA)
Galanthus nivalis lectin or agglutinin (GNL/GNA) is isolated from snowdrop bulbs. GNL consists of four identical subunits with a molecular weight of 50,000 and an isoelectric point between pH 3.5 and pH 4.0. Galanthus nivalis lectin, unlike most mannose-specific lectins, is not a metalloprotein and does not require Ca++or Mn++ for binding.
This lectin is known to agglutinate rabbit erythrocytes but not human erythrocytes. GNL contains little to no carbohydrate and specifically binds to murine IgM immunoglobin and human beta2-macroglobulin, but not to alpha-linked glucose (unlike majority of mannose-binding lectins). Structures containing (beta-1,3) mannose residues are preferred for binding and elutes with the sugar Mannose. GNL is useful for HIV research, applicable for blood cell agglutination studies, and has set a model system to help understand the molecular basis of how proteins recognize carbohydrates.
GLN is used for blood cell agglutination studies, HIV research, virus isolation, mouse IgM isolation.
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