Anti-Atg16L (Human) pAb
Cat# PM040
Size : 100ug
Brand : MBL International
Contact local distributor :
Phone : +1 850 650 7790
Please Note: MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: https://www.cosmobiousa.com/. For Non-US inquiries reach out to MBL in Japan: https://www.mblbio.com/.
| Target | Atg16L |
|---|---|
| Product Type | Antibody |
| Application | ICC, IP, WB |
| Clonality | Polyclonal |
| Conjugate | Unlabeled |
| Isotype | Affinity Purified Ig |
| Immunogen | Recombinant human ATG16L1 TV2 (85-588 a.a.) |
| Host Species | Rabbit |
| Species Reactivity | Human, Hamster, Mouse, Rat |
| Formulation | PBS containing 50% glycerol, pH 7.2. No preservative is contained. |
| Research Area | Cancer, Immunology, Autophagy |
| Description/Background | Autophagy is a process of intracellular bulk degradation in which cytoplasmic components including organelles are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. Autophagy has two ubiquitin-like conjugation systems, the Atg12 and LC3-II systems. In the Atg12 conjugation system, the Atg16L-Atg12-Atg5 forms 800 kDa complex that elongate autophagic isolation membrane. After completion of the formation of the autophagosome, the Atg12-Atg5-Atg16L complex dissociates from the membrane. In recent study, nonsynonymous SNP analysis has indicated that ATG16L1 is a Crohn’s disease susceptibility gene. |
| Storage Temperature | -20°C |
| Protocols | ICC, IP, WB |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |