Anti-CD41/ITGA2B antibody (Clone: HIP8) {AF647}

Clonality:	Monoclonal
Clone ID:	HIP8
Conjugation:	AF647
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	ITGA2B
Gene ID:	3674
Uniprot ID:	ITA2B_HUMAN

Tissue Specificity	Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines. Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level).
Function	Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface.
Protein Name	Integrin Alpha-Iib Gpalpha Iib Gpiib Platelet Membrane Glycoprotein Iib Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-216083 Reactome: R-HSA-3000178 Reactome: R-HSA-354192 Reactome: R-HSA-354194 Reactome: R-HSA-372708 Reactome: R-HSA-445144 Reactome: R-HSA-5674135 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-8936459 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223
Cellular Localisation	Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-Integrin Alpha-Iib antibody Anti-Gpalpha Iib antibody Anti-Gpiib antibody Anti-Platelet Membrane Glycoprotein Iib antibody Anti-Cd Antigen Cd41 Cleaved Into - Integrin Alpha-Iib Heavy Chain - Integrin Alpha-Iib Light Chain - Form 1 - Integrin Alpha-Iib Light Chain - Form 2 antibody Anti-ITGA2B antibody Anti-GP2B antibody Anti-ITGAB antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance