Anti-Cd86 antibody (Clone: GL-1) {PE/Cyanine7}

Clonality:	Monoclonal
Clone ID:	GL-1
Conjugation:	PE/Cyanine7
Isotype:	IgG2ak
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Concentration:	0.2 mg/mL
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	Cd86
Gene ID:	12524
Uniprot ID:	CD86_MOUSE

Tissue Specificity	Expressed on activated B-cells.
Post Translational Modifications	Polyubiquitinated.which is promoted by MARCH8 and results in endocytosis and lysosomal degradation.
Function	Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation.
Protein Name	T-Lymphocyte Activation Antigen Cd86 Activation B7-2 Antigen Early T-Cell Costimulatory Molecule 1 Etc-1 Cd Antigen Cd86
Database Links	Reactome: R-MMU-1257604 Reactome: -MMU-389356 Reactome: -MMU-389357 Reactome: -MMU-389359 Reactome: -MMU-389513 Reactome: -MMU-6811558
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative Antibody Names	Anti-T-Lymphocyte Activation Antigen Cd86 antibody Anti-Activation B7-2 Antigen antibody Anti-Early T-Cell Costimulatory Molecule 1 antibody Anti-Etc-1 antibody Anti-Cd Antigen Cd86 antibody Anti-Cd86 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance