Anti-CD9 antibody (Clone: HI9a) {APC}

Clonality:	Monoclonal
Clone ID:	HI9a
Conjugation:	APC
Isotype:	IgG1k
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Storage Instruction:	Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product.

Gene Symbol:	CD9
Gene ID:	928
Uniprot ID:	CD9_HUMAN

Tissue Specificity	Detected in platelets (at protein level). Expressed by a variety of hematopoietic and epithelial cells.
Post Translational Modifications	Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion.
Function	Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion. In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration. In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Acts as a receptor for PSG17. Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis.
Protein Name	Cd9 Antigen 5h9 Antigen Cell Growth-Inhibiting Gene 2 Protein Leukocyte Antigen Mic3 Motility-Related Protein Mrp-1 Tetraspanin-29 Tspan-29 P24 Cd Antigen Cd9
Database Links	Reactome: R-HSA-114608 Reactome: R-HSA-1300645 Reactome: R-HSA-5336415
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein Membrane Secreted Extracellular Exosome Present At The Cell Surface Of Oocytes Accumulates In The Adhesion Area Between The Sperm And Egg Following Interaction Between Izumo1 And Its Receptor Izumo1r/Juno
Alternative Antibody Names	Anti-Cd9 Antigen antibody Anti-5h9 Antigen antibody Anti-Cell Growth-Inhibiting Gene 2 Protein antibody Anti-Leukocyte Antigen Mic3 antibody Anti-Motility-Related Protein antibody Anti-Mrp-1 antibody Anti-Tetraspanin-29 antibody Anti-Tspan-29 antibody Anti-P24 antibody Anti-Cd Antigen Cd9 antibody Anti-CD9 antibody Anti-MIC3 antibody Anti-TSPAN29 antibody Anti-GIG2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance