• SKU DIA-PD1-OD
    Specificity

    PD-1
    Species Reactivity

    Human
    Host Species

    Mouse
    Isotype

    IgG2b
    Clone

    JAD1
    Clonality (Mono-/Polyclonal)

    monoclonal
    Application

    ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
    Conjugation

    unconjugated
    Dilution

    Immunohistochemistry (IHC): 1:100 – 1:400
    Format

    < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
    Product line / Topic

    Immuno-Oncology, Tumor Marker / Biology
    Intended Use

    for In vitro Diagnostic Use
    Temperature - Storage

    2-8°C
    Temperature - Transport

    cooled
    Search Code

    CD279, PD-1, PD1, DIAPD1, IHC, FFPE, Paraffin
    Manufacturer / Brand

    dianova
    Uniprot_ID

    Q15116
    Gene_ID

    5133
    Alias

    CD279, HPD1P, PD-1, PDCD1, Programmed Cell Death Protein 1, SLEB2
  • PD-1 (Programmed Cell-Death 1) is expressed by germinal center-associated T cells in reactive lymphoid tissue. PD-1 (CD279, PDCD1, SLEB2) plays a key role in peripheral tolerance and autoimmune disease. Several tumors express ligand for PD1 (PDL1). On binding activated T cells in the tumor microenvironment, PD-1 inactivates antigen specific T cells that would other-wise attack tumor cells. Monoclonal antibodies to PD1 and PDL1 are currently being investigated in clinical trials for their potential to inhibit this pathway with the effect of elevated tumor immunity. Moreover, antibodies directed to PD-1 are also used for di-agnosing certain T-cell derived lymphomas.