Anti-PDE2A antibody (1-50) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Formulation:	Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide).
Purification:	Affinity Purified
Concentration:	0.5 µg/µl
Dilution Range:	WB: 1:500 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PDE2A
Gene ID:	5138
Uniprot ID:	PDE2A_HUMAN
Immunogen Region:	1-50
Specificity:	This antibody will detect PDE2A1 only.
Immunogen:	Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A1 protein.

Tissue Specificity	Widely expressed. Expressed in brain, with high expression observed in the corpus striatum. Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas.
Function	cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
Protein Name	Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase Cyclic Gmp-Stimulated Phosphodiesterase Cgs-Pde Cgspde
Database Links	Reactome: R-HSA-418457 Reactome: R-HSA-418555
Cellular Localisation	Isoform Pde2a3: Cell Membrane Lipid-Anchor Isoform Pde2a2: Mitochondrion Matrix Mitochondrion Inner Membrane Mitochondrion Outer Membrane Isoform Pde2a1: Cytoplasm Isoform 5: Mitochondrion
Alternative Antibody Names	Anti-Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase antibody Anti-Cyclic Gmp-Stimulated Phosphodiesterase antibody Anti-Cgs-Pde antibody Anti-Cgspde antibody Anti-PDE2A antibody

Information sourced from Uniprot.org

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