General Info
| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Bovine/Human/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Phospho-Phospholipase A2 (30-80) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.55-0.75 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | PLAA |
| Gene ID: | 9373 |
| Uniprot ID: | PLAP_HUMAN |
| Immunogen Region: | 30-80 |
| Immunogen: | Synthetic peptide taken within amino acid region 30-80 on human Phospholipase A2-activating protein. |
Description
| Function | Plays a role in protein ubiquitination, sorting and degradation through its association with VCP. Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling. May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis. |
| Protein Name | Phospholipase A-2-Activating ProteinPla2pPlap |
| Cellular Localisation | NucleusCytoplasmSynapseRecruited To Damaged Lysosomes Decorated With K48-Linked Ubiquitin Chains |
| Alternative Antibody Names | Anti-Phospholipase A-2-Activating Protein antibodyAnti-Pla2p antibodyAnti-Plap antibodyAnti-PLAA antibodyAnti-PLAP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance