General Info
| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Human/Monkey/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-SOX10 (10-60) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.55-0.75 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:150IHC: 1:50-1:150 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | SOX10 |
| Gene ID: | 6663 |
| Uniprot ID: | SOX10_HUMAN |
| Immunogen Region: | 10-60 |
| Immunogen: | Synthetic peptide taken within amino acid region 10-60 on human Transcription Factor SOX-10 protein. |
Description
| Tissue Specificity | Expressed in fetal brain and in adult brain, heart, small intestine and colon. |
| Function | Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3. Transcriptional activator of MBP, via binding to the gene promoter. |
| Protein Name | Transcription Factor Sox-10 |
| Database Links | Reactome: R-HSA-9619665Reactome: R-HSA-9764302 |
| Cellular Localisation | CytoplasmNucleusMitochondrion Outer MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Transcription Factor Sox-10 antibodyAnti-SOX10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance