General Info
Host: | Rabbit |
Applications: | ELISA/WB |
Reactivity: | Cat/Human/Mouse/Pig |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-TLR7 (175-225) is suitable for use in ELISA and Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Biotin |
Isotype: | IgG |
Purification: | Affinity Purified |
Concentration: | 0.65-0.72 µg/µl |
Dilution Range: | WB: 1:500 DB: 1:20, 000 ELISA: 1:20, 000 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
Gene Symbol: | TLR7 |
Gene ID: | 51284 |
Uniprot ID: | TLR7_HUMAN |
Immunogen Region: | 175-225 |
Immunogen: | Synthetic peptide taken within amino acid region 175-225 on human TLR7 protein. |
Description
Tissue Specificity | Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Expressed in peripheral mononuclear blood cells. |
Function | Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. |
Protein Name | Toll-Like Receptor 7 |
Database Links | Reactome: R-HSA-1679131 Reactome: R-HSA-168181 Reactome: R-HSA-9679191 Reactome: R-HSA-9692916 Reactome: R-HSA-9705671 Reactome: R-HSA-975110 Reactome: R-HSA-975138 Reactome: R-HSA-975155 |
Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type I Membrane Protein Endosome Lysosome Cytoplasmic Vesicle Phagosome Relocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Stimulation With Agonist |
Alternative Antibody Names | Anti-Toll-Like Receptor 7 antibody Anti-TLR7 antibody Anti-UNQ248 antibody Anti-PRO285 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance