CD59 antibody [MEM-43/5] (PE)
Cat# GTX75576-100test
Size : 100test
Brand : GeneTex
Host | Mouse |
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Clonality | Monoclonal |
Clone Name | MEM-43/5 |
Isotype | IgG2b |
Application | FACS |
Reactivity | Human, Monkey |
Package | 100 test |
View product citations for antibody GTX75576 on CiteAb
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application | Recommended Dilution |
---|---|
FACS | Neat |
Note : FACSUse 10μl of the suggested working dilution to label 106 cells in 100μl. |
Not tested in other applications.
Calculated MW
14 kDa. ( Note )
PROPERTIES
Form
Liquid
Buffer
PBS, 1% BSA
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Purification
Protein A purified
Conjugation
Phycoerythrin (PE)
RRID
AB_376901
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CD59 molecule (CD59 blood group) , 16.3A5 , 1F5 , EJ16 , EJ30 , EL32 , G344 , HRF-20 , HRF20 , MAC-IP , MACIF , MEM43 , MIC11 , MIN1 , MIN2 , MIN3 , MIRL , MSK21 , p18-20
Cellular Localization
Secreted
Background
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Database
Application Reference
Miller-Novak LK et al. J Virol 2018; (Epub) Analysis of complement-mediated lysis of SIV and SIV-infected cells reveals sex differences in vaccine-induced immune responses in Rhesus macaques.
Application : FACS
Reactivity : Monkey
REVIEW
Application Reference
Miller-Novak LK et al. J Virol 2018; (Epub) Analysis of complement-mediated lysis of SIV and SIV-infected cells reveals sex differences in vaccine-induced immune responses in Rhesus macaques.
Application : FACS
Reactivity : Monkey
SDS | |
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PBS.pdf | |
Sodium Azide.pdf |