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> CHIR-99021 [252917-06-9]

CHIR-99021 [252917-06-9]

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Cat# 10-1279-25mg

Size : 25mg

Brand : Focus Biomolecules

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CHIR-99021 | GSK3ß inhibitor

CAS:
252917-06-9
Catalog Number:
10-1279
Activity:
GSK3β inhibitor
Chemical Name:
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Molecular Weight:
465.35
Molecular Formula:
C22H18Cl2N8
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Tan solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

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5 mg$65.00
25 mg$175.00
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CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM).1 Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells.2 Promotes replication and survival of pancreatic beta cells.3 CHIR-99021 enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors.4 Cell permeable and active in vivo.  Wnt activator.

References/Citations:

1) Bennett et al. (2002), Regulation of Wnt signaling during adipogenesis; J. Biol. Chem., 277 30998
2) Bennett et al. (2005), Regulation of osteoblastogenesis and bone mass by Wnt10b; Proc. Natl. Acad. Sci. USA, 102 3324
3) Mussmann et al. (2007), Inhibition of GSK3 promotes replication and survival of pancreatic beta cells; J. Biol. Chem., 282 12030
4) Manceur et al. (2011), Inhibition of glycogen synthase kinase-3 enhances the differentiation and reduces the proliferation of adult human olfactory epithelium neural precursors; Exp. Cell. Res., 317 2086
5) Takaoka et al. (2016), Live imaging of transforming growth factor-β activated kinase 1 activation in Lewis Lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid; Cancer Sci., 107 644 [Focus Citation]

CAS:
252917-06-9
Catalog Number:
10-1279
Activity:
GSK3β inhibitor
Chemical Name:
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Molecular Weight:
465.35
Molecular Formula:
C22H18Cl2N8
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Tan solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a restocking/refund fee

CHIR-99021 (252917-06-9) is a potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM).1 Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells.2 Promotes replication and survival of pancreatic beta cells.3 CHIR-99021 enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors.4 Cell permeable and active in vivo.  Wnt activator.

References/Citations:

1) Bennett et al. (2002), Regulation of Wnt signaling during adipogenesis; J. Biol. Chem., 277 30998
2) Bennett et al. (2005), Regulation of osteoblastogenesis and bone mass by Wnt10b; Proc. Natl. Acad. Sci. USA, 102 3324
3) Mussmann et al. (2007), Inhibition of GSK3 promotes replication and survival of pancreatic beta cells; J. Biol. Chem., 282 12030
4) Manceur et al. (2011), Inhibition of glycogen synthase kinase-3 enhances the differentiation and reduces the proliferation of adult human olfactory epithelium neural precursors; Exp. Cell. Res., 317 2086
5) Takaoka et al. (2016), Live imaging of transforming growth factor-β activated kinase 1 activation in Lewis Lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid; Cancer Sci., 107 644 [Focus Citation]