Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dihydrostreptomycin sulfate [5490-27-7]
Dihydrostreptomycin sulfate
Catalog No. T2211 CAS 5490-27-7
Synonyms: Dihydrostreptomycin sesquisulfate
Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) inhibits protein synthesis by binding to the 30S ribosomal subunit. Dihydrostreptomycin Sulfate is a semi-synthetic aminoglycoside antibiotic with bactericidal properties. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tularemia.
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Dihydrostreptomycin sulfate, CAS 5490-27-7
| Pack Size | /USD | |
|---|---|---|
| 500 mg | In stock | |
| 1 g | In stock |
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Purity: 99.93%
Purity: 99.05%
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| Description | Dihydrostreptomycin sulfate (Dihydrostreptomycin sesquisulfate) inhibits protein synthesis by binding to the 30S ribosomal subunit. Dihydrostreptomycin Sulfate is a semi-synthetic aminoglycoside antibiotic with bactericidal properties. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tularemia. |
| In vitro | The primary mechanism of action of the antibiotic dihydrostreptomycin is binding to and modifying the function of the bacterial ribosome, thus leading to decreased and aberrant translation of proteins. It enters bacterial cells by binding to a specific site on MscL(mechanosensitive channel of large conductance) and modifying its conformation, thus allowing the passage of K+ and glutamate out of, and dihydrostreptomycin into, the cell[1]. |
| In vivo | Dihydrostreptomycin sulfate would cause cochlea damage in mouse model and cell proliferation in the spiral ligament may occur after the dihydrostreptomycin sulfate -induced damage. This process is probably related to the recovery of cochlear function[2]. |
| Kinase Assay | Briefly, the peptide substrate N-acetyl-Asp-Glu-Val-Asp-ρ-nitroanilide (Ac-DEVD-ρNA) is added to the cell lysates in assay buffer (50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 10 mM dithiothreitol, 1 mM EDTA, 10% glycerol) and incubated at 37°C. The cleavage of the substrate is monitored at 405 nm. |
| Synonyms | Dihydrostreptomycin sesquisulfate |
| Molecular Weight | 730.71 |
| Formula | C21H41N7O12·1·5H2SO4 |
| CAS No. | 5490-27-7 |
Storage
Solubility Information
H2O: 10 mM
DMSO: Insoluble
References and Literature
1. Kimitsuki T, et al. Brain Res. 1993, 624(1-2):143-150. 2. Yamashita H, et al. Acta Otolaryngol. 1999, 119(3):322-325.
Related compound libraries
This product is contained In the following compound libraries：
Natural Product Library Drug Repurposing Compound Library Natural Product Library for HTS Microbial Natural Product Library Anti-Infection Compound Library Antibiotics Library Approved Drug Library Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Bioactive Compounds Library Max
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Keywords
Dihydrostreptomycin sulfate 5490-27-7 Microbiology/Virology Antibacterial Antibiotic inhibit Dihydrostreptomycin Sulfate Dihydrostreptomycin sesquisulfate Inhibitor Dihydrostreptomycin Bacterial inhibitor