ALS11283 | DKK1 Antibody (C-Terminus) Clinisciences

Product Information
Application Applications Legend: WB=Western Blot IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin-embedded Sections) IHC-F=Immunohistochemistry (Frozen Sections) IF=Immunofluorescence FC=Flow Cytopmetry IC=Immunochemistry ICC=Immunocytochemistry E=ELISA IP=Immunoprecipitation DB=Dot Blot CHIP=Chromatin Immunoprecipitation FA=Fluorescence Assay IEM=Immuno electron microscopy EIA=Enzyme Immunoassay	WB, IHC-P, E
Primary Accession	O94907
Reactivity	Human, Mouse, Monkey, Pig, Goat, Horse, Bovine, Dog
Host	Goat
Clonality	Polyclonal
Calculated MW	29kDa
Dilution	ELISA (1:128000), IHC-P (10 µg/ml), WB (1-3 µg/ml)

Additional Information
Gene ID	22943
Other Names	Dickkopf-related protein 1, Dickkopf-1, Dkk-1, hDkk-1, SK, DKK1
Target/Specificity	Human DKK1.
Reconstitution & Storage	Store at -20°C. Minimize freezing and thawing.
Precautions	DKK1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	DKK1
Function	Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Cellular Location	Secreted.
Tissue Location	Placenta.

DKK1 Antibody (C-Terminus)