DMAP1 Polyclonal Antibody
Cat# bs-13009R
Size : 100ul
Brand : Bioss
Contact local distributor :
Phone : +1 850 650 7790
DMAP1 Polyclonal Antibody
Applications
Reactivity
Predicted Reactivity
| Overview | |
| Catalog # | bs-13009R |
| Product Name | DMAP1 Polyclonal Antibody |
| Applications | ELISA, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F), IF(ICC), ICC |
| Reactivity | Xenopus laevis |
| Predicted Reactivity | Human, Mouse, Rat, Dog, Cow, Sheep, Chicken, Rabbit |
| Specifications | |
| Conjugation | Unconjugated |
| Host | Rabbit |
| Source | KLH conjugated synthetic peptide derived from human DMAP1 |
| Immunogen Range | 31-130/467 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1ug/ul |
| Purification | Purified by Protein A. |
| Storage Buffer | 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Storage Condition | Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| Target | |
| Gene ID | 55929 |
| Subcellular location | Cytoplasm, Nucleus |
| Synonyms | DKFZp686L09142; DMAP 1; DNA methyltransferase 1-associated protein 1; DNMAP 1; DNMAP1; DNMT1-associated protein 1; DNMT1-associated protein 1; DNMTAP 1; DNMTAP1; EAF 2; EAF2; FLJ11543; KIAA1425; MAT 1-mediated transcriptional repressor; MGC55593; SWC 4; SWC4; zgc:55593. |
| Background | Methylation of DNA contributes to the regulation of gene transcription in eukaryotic systems. DNA methylation is predominantly found on cytosine residues that are present in dinucleotide motifs consisting of a 5' cytosine followed by a guanosine (CpG), and it requires the enzymatic activity of DNA methyltransferases (DNMTs), which results in transcriptional repression of the methylated gene. DNA methyltransferase 1-associating protein (Dmap1) binds to methyl-CpG rich domains and mediate the transcriptional inhibition associated with DNA methylation. Dmap1 interacts with Daxx to enhanced Daxx-mediated repression of glucocorticoid receptor transcriptional activity. Daxx also protects Dmap1 from protein degradation in vivo. |
| Application Dilution | |
| ELISA | 1:500-1000 |
| IHC-P | 1:200-400 |
| IHC-F | 1:100-500 |
| IF(IHC-P) | 1:50-200 |
| IF(IHC-F) | 1:50-200 |
| IF(ICC) | 1:50-200 |
| ICC | 1:100-500 |