DPI 201-106 [97730-95-5]
Cat# HY-19666-5mg
Size : 5mg
Brand : MedChemExpress
DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect.
For research use only. We do not sell to patients.
DPI 201-106 Chemical Structure
CAS No. : 97730-95-5
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Description |
DPI 201-106 (SDZ 201106) is a cardiotonic agent with a synergistic sarcolemmal and intracellular mechanism of action. DPI 201-106 shows cardioselective modulation of voltage-gated sodium channels (VGSCs) resulting in a positive inotropic effect[1][2][3]. |
IC50 & Target |
Sodium Channel[3] |
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In Vitro |
DPI 201-106 increases the Ca2+-sensitivity of skinned fibres from porcine trabecula septomarginalis with an EC50 of 0.2 nM[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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In Vivo |
In anesthetized dogs, left ventricular dP/dtmax is increased by DPI 201-106 0.2 mg/kg i.v.In digoxin-pretreated anesthetized cats, DPI 201-106 is infused up to an accumulated dose of 12.22 mg/kg i.v. [3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Molecular Weight |
466.57 |
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Formula |
C29H30N4O2 |
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CAS No. |
97730-95-5 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
N#CC(N1)=CC2=C1C=CC=C2OCC(O)CN3CCN(C(C4=CC=CC=C4)C5=CC=CC=C5)CC3 |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
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Solvent & Solubility |
In Vitro:
DMSO : 250 mg/mL (535.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO
+
%
+
%
Tween-80
+
%
Saline
The co-solvents required include: DMSO,
. All of co-solvents are available by MedChemExpress (MCE).
, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration:
mg/mL
Method for preparing stock solution:
mg
drug dissolved in
μL
DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take
μL DMSO stock solution, add
μL .
μL , mix evenly, next add
μL Tween 80, mix evenly, then add
μL Saline.
If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
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Purity & Documentation |
Purity: 99.98% |
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References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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DMSO | 1 mM | 2.1433 mL | 10.7165 mL | 21.4330 mL | 53.5825 mL |
5 mM | 0.4287 mL | 2.1433 mL | 4.2866 mL | 10.7165 mL | |
10 mM | 0.2143 mL | 1.0717 mL | 2.1433 mL | 5.3583 mL | |
15 mM | 0.1429 mL | 0.7144 mL | 1.4289 mL | 3.5722 mL | |
20 mM | 0.1072 mL | 0.5358 mL | 1.0717 mL | 2.6791 mL | |
25 mM | 0.0857 mL | 0.4287 mL | 0.8573 mL | 2.1433 mL | |
30 mM | 0.0714 mL | 0.3572 mL | 0.7144 mL | 1.7861 mL | |
40 mM | 0.0536 mL | 0.2679 mL | 0.5358 mL | 1.3396 mL | |
50 mM | 0.0429 mL | 0.2143 mL | 0.4287 mL | 1.0717 mL | |
60 mM | 0.0357 mL | 0.1786 mL | 0.3572 mL | 0.8930 mL | |
80 mM | 0.0268 mL | 0.1340 mL | 0.2679 mL | 0.6698 mL | |
100 mM | 0.0214 mL | 0.1072 mL | 0.2143 mL | 0.5358 mL |