EGFR Human Gene Knockout Kit (CRISPR)
CAT#: KN214877RB
EGFR - human gene knockout kit via CRISPR, HDR mediated
Functional Cassette: GFP-puro Luciferase-Puro mBFP-Neo
HDR-mediated knockout kit validation
Specifications
Product Data | |
Format | 2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control |
Donor DNA | RFP-BSD |
Symbol | EGFR |
Locus ID | 1956 |
Components | KN214877G1, EGFR gRNA vector 1 in pCas-Guide CRISPR vector KN214877G2, EGFR gRNA vector 2 in pCas-Guide CRISPR vector KN214877RBD, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector |
Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process. |
Reference Data | |
RefSeq | NM_005228, NM_201282, NM_201283, NM_201284, NM_001346897, NM_001346898, NM_001346899, NM_001346900, NM_001346941 |
UniProt ID | P00533 |
Synonyms | ERBB; ERBB1; HER1; mENA; NISBD2; PIG61 |
Summary | The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020] |
Documents
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Other Versions
SKU | Description | Size | |
---|---|---|---|
KN214877 | EGFR - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
KN214877BN | EGFR - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
KN214877LP | EGFR - human gene knockout kit via CRISPR, HDR mediated | 1 657,00 EUR | |
KN414877 | EGFR - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. | 1 657,00 EUR | |
GA101355 | EGFR CRISPRa kit - CRISPR gene activation of human epidermal growth factor receptor | 1 657,00 EUR |