FRAT1 belongs to the GSK-3-binding protein family. It may function in tumor progression and in lymphomagenesis. It positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. It may play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.
Research Articles on Frequently Rearranged In Advanced T-Cell Lymphomas 1 (FRAT1)
| Target | Frequently Rearranged In Advanced T-Cell Lymphomas 1 (FRAT1) |
| Clonality | Polyclonal |
| Reactivity | Human |
| Tested Applications | ELISA, WB, IHC |
| Host | Rabbit |
| Recommended dilutions | WB: 1/1000, IHC-P: 1/10 - 1/50. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Conjugation | Unconjugated |
| Immunogen | KLH-conjugated synthetic peptide between 99-128 amino acids from the Central region of human FRAT1. |
| Isotype | IgG |
| Form | Liquid |
| Purification | Purified Rabbit Polyclonal Antibody. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| UniProt Primary AC | Q92837 (UniProt, ExPASy) |
| UniProt Secondary AC | Q5JTI1, Q8NE74, Q8TDW9 |
| UniProt Entry Name | FRAT1_HUMAN |
| KEGG | hsa:10023 |
| String | 9606.ENSP00000360060 |
| Molecular Weight | Calculated MW: 29.1 kDa |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Note | This product is for research use only. |