Reagents and instruments for immunology, cell biology and molecular biology.
 
> hnRNP Q (dJ3J17.2, Glycine and Tyrosine rich RNA Binding Protein, GRY RBP, Heterogeneous Nuclear Ribonucleoprotein Q, HNRPQ 1, HNRPQ, HNRPQ1, NS1 Associated Protein 1, NSAP 1, NSAP1, pp68, RP1 3J17.2, Synaptotagmin Binding cytoplasmic RNA Interacting Protein, SYNCRIP)

hnRNP Q (dJ3J17.2, Glycine and Tyrosine rich RNA Binding Protein, GRY RBP, Heterogeneous Nuclear Ribonucleoprotein Q, HNRPQ 1, HNRPQ, HNRPQ1, NS1 Associated Protein 1, NSAP 1, NSAP1, pp68, RP1 3J17.2, Synaptotagmin Binding cytoplasmic RNA Interacting Protein, SYNCRIP)

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Cat# 254112-100ul

Size : 100ul

Brand : US Biological

Contact local distributor :


Phone : +1 850 650 7790

254112 Rabbit Anti-hnRNP Q (dJ3J17.2, Glycine and Tyrosine rich RNA Binding Protein, GRY RBP, Heterogeneous Nuclear Ribonucleoprotein Q, HNRPQ 1, HNRPQ, HNRPQ1, NS1 Associated Protein 1, NSAP 1, NSAP1, pp68, RP1 3J17.2, Synaptotagmin Binding cytoplasmic RNA Interacting Protein, SYNCRIP)

Clone Type
Polyclonal
Host
mouse
Source
human
Isotype
IgG1
Grade
Affinity Purified
Applications
E FC IC IF IP WB
Crossreactivity
Hu Mo Xe
Shipping Temp
Blue Ice
Storage Temp
-20°C

Spinal muscular atrophy (SMA) is a common neurodegenerative disease caused by deletion or loss-of-function mutations of the survival of motor neurons (SMN) protein. SMN is complexed with several proteins including Gemin2 Gemin3 and Gemin4 and plays important roles in small nuclear ribonucleoprotein (snRNP) biogenesis and in pre-mRNA splicing. The hnRNP Q proteins interact with SMN they are required for efficient pre-mRNA splicing in vitro. The hnRNP Q proteins may provide a molecular link between the SMN complex and splicing.||Applications: |Suitable for use in Immunofluorescence, Flow Cytometry, ELISA, Western Blot, Immunoprecipitation, Immunocytochemistry. Other applications not tested.||Recommended Dilution:|Flow Cytometry: 1ug for 10e6 cells.|Western Blot: Use at an assay dependent dilution. Detects a band of ~55,60,70kD (predicted molecular weight: 70kD).|Optimal dilutions to be determined by the researcher.||Hybridoma: |Sp2/0 myeloma cells with spleen cells from Balb/c mice.||Storage and Stability:|May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Applications
Product Type: Mab|Isotype: IgG1|Clone No: I8E4|Host: mouse|Source: human|Concentration: ~1mg/ml|Form: Supplied as a liquid in PBS, 0.09% sodium azide.|Purity: Purified by Protein A affinity chromatography.|Immunogen: Recombinant protein untagged hnRNP-Q protein (human)|Specificity: Recognizes hnRNP Q. Species Crossreactivity: Mouse, Human, Xenopus laevis||Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Immunogen
Recombinant protein untagged hnRNP-Q protein (human)
Form
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity
Purified by Protein A affinity chromatography.
Specificity
Recognizes hnRNP Q. Species Crossreactivity: Mouse, Human, Xenopus laevis
References
1. Katoh H  et al. Japanese Encephalitis Virus Core Protein Inhibits Stress Granule Formation through an Interaction with Caprin-1 and Facilitates Viral Propagation. J Virol 87:489-502 (2013). WB. 2. Peddigari S  et al. hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition. Nucleic Acids Res 41:575-85 (2013). WB ; Human. 3. Evans JD  et al. Paired mutations abolish and restore the balanced annealing and melting activities of ORF1p that are required for LINE-1 retrotransposition. Nucleic Acids Res 39:5611-21 (2011). WB ; Human. 4. Krüger M  et al. Dissection of the insulin signaling pathway via quantitative phosphoproteomics. Proc Natl Acad Sci U S A 105:2451-6 (2008). WB ; Mouse. 5. Fu D & Collins K Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation. Mol Cell 28:773-85 (2007). IP ; Human. 6. Hogg JR & Collins K RNA-based affinity purification reveals 7SK RNPs with distinct composition and regulation. RNA 13:868-80 (2007). WB ; Human. 7. Van Herreweghe E  et al. Dynamic remodelling of human 7SK snRNP controls the nuclear level of active P-TEFb. EMBO J 26:3570-80 (2007). WB ; Human.