Human AAP (Alanine Aminopeptidase) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	ANPEP
Gene ID:	290
Uniprot ID:	AMPN_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Expressed in epithelial cells of the kidney, intestine, and respiratory tract.granulocytes, monocytes, fibroblasts, endothelial cells, cerebral pericytes at the blood-brain barrier, synaptic membranes of cells in the CNS. Also expressed in endometrial stromal cells, but not in the endometrial glandular cells. Found in the vasculature of tissues that undergo angiogenesis and in malignant gliomas and lymph node metastases from multiple tumor types but not in blood vessels of normal tissues. A soluble form has been found in plasma. It is found to be elevated in plasma and effusions of cancer patients.
Post Translational Modifications	Sulfated. N- and O-glycosylated. May undergo proteolysis and give rise to a soluble form.
Function	Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity. (Microbial infection) Acts as a receptor for human coronavirus 229E/HCoV-229E. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. (Microbial infection) Mediates as well Human cytomegalovirus (HCMV) infection.
Protein Name	Aminopeptidase N Ap-N Hapn Alanyl Aminopeptidase Aminopeptidase M Ap-M Microsomal Aminopeptidase Myeloid Plasma Membrane Glycoprotein Cd13 Gp150 Cd Antigen Cd13
Database Links	Reactome: R-HSA-2022377 Reactome: R-HSA-6798695
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Also Found As A Soluble Form
Alternative ELISA Names	Aminopeptidase N ELISA kit Ap-N ELISA kit Hapn ELISA kit Alanyl Aminopeptidase ELISA kit Aminopeptidase M ELISA kit Ap-M ELISA kit Microsomal Aminopeptidase ELISA kit Myeloid Plasma Membrane Glycoprotein Cd13 ELISA kit Gp150 ELISA kit Cd Antigen Cd13 ELISA kit ANPEP ELISA kit APN ELISA kit CD13 ELISA kit PEPN ELISA kit
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Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance