Human FZD6 (Frizzled Homolog 6) Sandwich ELISA Kit

Cat# NB-22-65000-48

Size : 48T

Brand : Neo Biotech

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  • Human FZD6 (Frizzled Homolog 6) Sandwich ELISA Kit

General Info

Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.119ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This FZD6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs

Information

Gene Symbol: FZD6
Gene ID: 8323
Uniprot ID: FZD6_HUMAN
Sample Type: tissue homogenates or other biological fluids.

Description

Tissue Specificity Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney.
Post Translational Modifications Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear.
Protein Name Frizzled-6
Fz-6
Hfz6
Database Links Reactome: R-HSA-373080
Reactome: R-HSA-4086398
Reactome: R-HSA-4086400
Reactome: R-HSA-4641263
Reactome: R-HSA-5340588
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cell Surface
Apical Cell Membrane
Cytoplasmic Vesicle Membrane
Endoplasmic Reticulum Membrane
Colocalizes With Fzd3 At The Apical Face Of Cells
Localizes To The Endoplasmic Reticulum Membrane In The Presence Of Lmbr1l
Alternative ELISA Names Frizzled-6 ELISA kit
Fz-6 ELISA kit
Hfz6 ELISA kit
FZD6 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance