General Info
Applications: | ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Sensitivity: | 0.119ng/mL |
Detection Limit: | 0.312-20ng/mL |
Short Description: | This FZD6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin). |
Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
Assay Time: | 4.5 hrs |
Information
Gene Symbol: | FZD6 |
Gene ID: | 8323 |
Uniprot ID: | FZD6_HUMAN |
Sample Type: | tissue homogenates or other biological fluids. |
Description
Tissue Specificity | Detected in adult heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, thymus, prostate, testis, ovary, small intestine and colon. In the fetus, expressed in brain, lung, liver and kidney. |
Post Translational Modifications | Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. |
Function | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear. |
Protein Name | Frizzled-6Fz-6Hfz6 |
Database Links | Reactome: R-HSA-373080Reactome: R-HSA-4086398Reactome: R-HSA-4086400Reactome: R-HSA-4641263Reactome: R-HSA-5340588 |
Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell MembraneCell SurfaceApical Cell MembraneCytoplasmic Vesicle MembraneEndoplasmic Reticulum MembraneColocalizes With Fzd3 At The Apical Face Of CellsLocalizes To The Endoplasmic Reticulum Membrane In The Presence Of Lmbr1l |
Alternative ELISA Names | Frizzled-6 ELISA kitFz-6 ELISA kitHfz6 ELISA kitFZD6 ELISA kit |
output |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance