Human IREM1 (Immune Receptor Expressed On Myeloid Cells 1) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	CD300LF
Gene ID:	146722
Uniprot ID:	CLM1_HUMAN
Immunogen Region:	Ready-To-Use
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Highly expressed in spleen, peripheral blood leukocyte and monocyte, and lung. Weakly expressed in thymus, heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine or colon. Expressed selectively in monocytes and monocyte-related cells.
Post Translational Modifications	Phosphorylated on tyrosine.
Function	Acts as an inhibitory receptor for myeloid cells and mast cells. Positively regulates the phagocytosis of apoptotic cells (efferocytosis) via phosphatidylserine (PS) recognition.recognizes and binds PS as a ligand which is expressed on the surface of apoptotic cells. Plays an important role in the maintenance of immune homeostasis, by promoting macrophage-mediated efferocytosis and by inhibiting dendritic cell-mediated efferocytosis. Negatively regulates Fc epsilon receptor-dependent mast cell activation and allergic responses via binding to ceramide and sphingomyelin which act as ligands. May act as a coreceptor for interleukin 4 (IL-4). Associates with and regulates IL-4 receptor alpha-mediated responses by augmenting IL-4- and IL-13-induced signaling. Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 and TRIF through activation of PTPN6/SHP-1 and PTPN11/SHP-2. Inhibits osteoclast formation. Induces macrophage cell death upon engagement.
Protein Name	Cmrf35-Like Molecule 1 Clm-1 Cd300 Antigen-Like Family Member F Immune Receptor Expressed On Myeloid Cells 1 Irem-1 Immunoglobulin Superfamily Member 13 Igsf13 Nk Inhibitory Receptor Cd Antigen Cd300f
Database Links	Reactome: R-HSA-198933
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein
Alternative ELISA Names	Cmrf35-Like Molecule 1 ELISA kit Clm-1 ELISA kit Cd300 Antigen-Like Family Member F ELISA kit Immune Receptor Expressed On Myeloid Cells 1 ELISA kit Irem-1 ELISA kit Immunoglobulin Superfamily Member 13 ELISA kit Igsf13 ELISA kit Nk Inhibitory Receptor ELISA kit Cd Antigen Cd300f ELISA kit CD300LF ELISA kit CD300F ELISA kit CLM1 ELISA kit IGSF13 ELISA kit IREM1 ELISA kit NKIR ELISA kit UNQ3105 ELISA kit PRO10111 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance