- More Files
- Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic protein of IL18.
Immunogen
Synthetic protein corresponding to C-terminus of IL18.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Lyophilized
Purification
Protein G affinity chromatography
Purity
>95%
Isotype
IgG
Recommend Usage
ELISA (1-2 ug/mL)
Immunohistochemistry (2-10 ug/mL)
Western Blot (2-10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4 (5% Trehalose).
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with 0.01 M PBS pH 7.4 or other diluents (such as distilled water), store at 2-8°C for one month, or at -20°C for six months without detectable loss of activity.
Aliquot to avoid repeated freezing and thawing. - Applications
Western Blot
Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
- Gene Info — IL18
Entrez GeneID
3606Protein Accession#
Q14116Gene Name
IL18
Gene Alias
IGIF, IL-18, IL-1g, IL1F4, MGC12320
Gene Description
interleukin 18 (interferon-gamma-inducing factor)
Omim ID
600953Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. [provided by RefSeq
Other Designations
IL-1 gamma|interferon-gamma-inducing factor|interleukin 18|interleukin-1 gamma|interleukin-18
- Interactomes
- Pathways
- Diseases
- Publication Reference
- Expression of human caspase-4 in the gingival epithelium affected with periodontitis: Its involvement in Porphyromonas gingivalis-challenged gingival epithelial cells.
Nutthapong Kantrong, Worakanya Buranaphatthana, Doosadee Hormdee, Waraporn Suwannarong, Rajda Chaichit, Komkham Pattanaporn, Poramaporn Klanrit, Suttichai Krisanaprakornkit.
Archives of Oral Biology 2022 Aug; 140:105466.
Application：IHC-P, Human, human gingiva.
- Using high-throughput sequencing to explore the anti-inflammatory effects of α-mangostin.
Yin P, Zou W, Li J, Jin N, Gao Q, Liu F.
Scientific Reports 2019 Oct; 9(1):15626.
Application：IHC-P, WB, Rat, Rat jejunum.
- Interleukin-18 modulation in autism spectrum disorders.
Businaro R, Corsi M, Azzara G, Di Raimo T, Laviola G, Romano E, Ricci L, Maccarrone M, Aronica E, Fuso A, Ricci S.
Journal of Neuroinflammation 2016 Jan; 13(1):2.
Application：IHC-P, Human, Mouse, Brains from human, Mouse.
- Excess aldosterone is a critical danger signal for inflammasome activation in the development of renal fibrosis in mice.
Kadoya H, Satoh M, Sasaki T, Taniguchi S, Takahashi M, Kashihara N.
FASEB Journal 2015 Sep; 29(9):3899.
Application：IF, Mouse, Kidney.
- WNT signaling underlies the pathogenesis of neuropathic pain in rodents.
Zhang YK, Huang ZJ, Liu S, Liu YP, Song AA, Song XJ.
The Journal of Clinical Investigation 2013 May; 123(5):2268.
Application：IF, IHC, WB-Ti, Rat, Rat spinal cords.
- Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status.
Nishi Y, Satoh M, Nagasu H, Kadoya H, Ihoriya C, Kidokoro K, Sasaki T, Kashihara N.
Kidney International 2013 Apr; 83(4):662.
Application：IHC, Mouse, Mouse kidney.
- Expression of human caspase-4 in the gingival epithelium affected with periodontitis: Its involvement in Porphyromonas gingivalis-challenged gingival epithelial cells.