IL6 Rabbit Polyclonal Antibody

CAT#: SP2128A

IL6 rabbit polyclonal antibody, Azide Free


Product Images

Specifications

Product Data
Applications ELISA, FN, WB
Recommended Dilution ELISA.
Western Blot: Detects a band of approximately 27kDa.
Functional Assays.
Reactivities Chicken
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant Chicken IL-6.
Specificity This antibody recognizes Chicken Interleukin 6 (chIL-6). Other species not tested.
This antibody Neutralizes IL-6 in 7D1 bioassays.
Formulation PBS
State: Azide Free
State: Liquid purified IgG fraction
Stabilizer: None
Preservative: None
Concentration lot specific
Purification Affinity Chromatography on protein G
Conjugation Unconjugated
Storage Upon receipt, store undiluted (in aliquots) at -20°C.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name interleukin 6
Background Mammalian IL-6 is a multifunctional pro-inflammatory cytokine, which plays a major role in the regulation of immune responses, haematopoiesis and the induction of acute phase responses. The action of IL-6 occurs via the signal transducing receptor chain gp130 and the IL-6 receptor alpha chain is responsible for ligand binding. IL-6 is produced by a wide variety of cells including B lymphocytes, T lymphocytes, monocytes/macrophages, fibroblasts and endothelial cells and has a widespread cellular effect, including B and T lymphocytes, hepatocytes and cells of the CNS.
Studies relating to the properties of chIL-6 have been limited, but demonstrate that hepatocyte-stimulating factor (HSF), secreted by lipopolysaccharide (LPS)-stimulated macrophages, induces fibronectin production in cultured chicken hepatocytes, and that HSF produced by LPS-treated fibroblasts, was neutralized by an antiserum to recombinant HuIL-6 (rHuIL-6). rHuIL-6 has also been shown as biologically active on chicken hepatocytes.
Synonyms IL-6, Interferon beta-2, IFNB2, B-cell stimulatory factor 2, BSF-2, CDF
Reference Data
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway

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