Kainic Acid Monohydrate (Digenin)

Kainic acid is a potent neuroexcitatory amino acid that acts as a neurotoxin in high doses. It was originally isolated from seaweed and is used in the study of the physiological effect of excitotoxicity and assess the neuroprotective capabilities of potential therapeutics. (-)-α-Kainic Acid Monohydrate is the monohydrated form of (-)-α-Kainic Acid; a naturally occurring neuroexcitatory chemical that is a selective agonist for a subtype of ionotropic glutamate receptor. Administration of (-)-α-Kainic Acid has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions and in the hilus of dentate gyrus.||Synonyms:|(2S,3S,4S)-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid Hydrate; [2S-(2α,3β,4β)]-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic Acid Monohydrate; Digenin ||Molecular Formula: |C10H15NO4•H2O||Molecular Weight:|231.25||CAS No: |58002-62-3|Anhydrous: 487-79-6||Purity: |≥98%||Appearance:|Cystalline solid||Melting Point:|>211°C (dec.) (lit)||Solubility:|DMSO (2mg/ml)||Storage and Stability:|May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.