• Specifications

    Product Description

    Mouse monoclonal antibody raised against native KRT6.

    Immunogen

    Native purified human KRT6.

    Host

    Mouse

    Reactivity

    Human, Mouse

    Specificity

    This antibody represents an excellent marker for non-keratinized squamous epithelia and proliferating cells of epidermis (e.g. within psoriatic lesions). It is suitable for discrimination of keratinizing and non-keratinizing squamous cell carcinoma versus e.g. poorly differentiated adenocarcinoma. Polypeptide reacting: Mr 56000 polypeptide (cytokeratin 6) of human squamous epithelia.

    Form

    Liquid

    Isotype

    IgG1

    Recommend Usage

    Immunohistochemistry (1:10)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In Tris, pH7.4 (0.5% BSA, 0.09% sodium azide)

    Storage Instruction

    Store at 4°C.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Western Blot

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)

    Immunohistochemistry (Frozen sections)

  • Gene Info — KRT6A

    Entrez GeneID

    3853

    Gene Name

    KRT6A

    Gene Alias

    CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D

    Gene Description

    keratin 6A

    Omim ID

    148041 167200

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq

    Other Designations

    56 cytoskeletal type II keratin|K6D keratin|cytokeratin 6A|cytokeratin 6C|cytokeratin 6D|keratin 6C|keratin, epidermal type II, K6A|keratin, epidermal type II, K6C|keratin, type II cytoskeletal 6D|type II keratin isoform K6c

  • Gene Info — KRT6B

    Entrez GeneID

    3854

    Gene Name

    KRT6B

    Gene Alias

    CK6B, K6B, KRTL1, PC2

    Gene Description

    keratin 6B

    Omim ID

    148042 167210

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq

    Other Designations

    cytokeratin 6B|keratin, epidermal, type II, K6B|keratin, type II cytoskeletal 6B|keratin-like 1 (a type II keratin sequence)

  • Gene Info — KRT6C

    Entrez GeneID

    286887

    Gene Name

    KRT6C

    Gene Alias

    K6E, KRT6E, MGC102925, MGC163455, MGC163457

    Gene Description

    keratin 6C

    Gene Ontology

    Hyperlink

    Gene Summary

    Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. The type II keratins are clustered in a region of chromosome 12q13. [provided by RefSeq

    Other Designations

    keratin 6E

  • Interactomes