Reagents and instruments for immunology, cell biology and molecular biology.

MCP-1 / MCAF, recombinant Human

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Cat# NB-50-0295-100

Size : 100µg

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Phone : +1 850 650 7790

Brand : Neo Biotech

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Phone : +1 850 650 7790

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Bioassay analysis of Human CCL2 (MCP-1) Recombinant Protein, PeproTech® (Product # 300-04-1MG).

Product Details

300-04-100UG

Applications

Tested Dilution

Publications

Western Blot (WB)

Assay-dependent

View 1 publication 1 publication

Immunohistochemistry (IHC)

View 1 publication 1 publication

ELISA (ELISA)

Assay-dependent

View 20 publications 20 publications

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 110 publications 110 publications

Competition Assay (CA)

View 1 publication 1 publication

Miscellaneous PubMed (Misc)

View 15 publications 15 publications

Product Specifications

Species

Human

Published species

Bacteria, Dog, Hamster, Human, Mouse, Non-human primate, Pig, Protozoa, Rat

Expression System

E. coli

Amino acid sequence

QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT

Molecular weight

8.6 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.

Molecular psychiatry

Albornoz EA,Amarilla AA,Modhiran N,Parker S,Li XX,Wijesundara DK,Aguado J,Zamora AP,McMillan CLD,Liang B,Peng NYG,Sng JDJ,Saima FT,Fung JN,Lee JD,Paramitha D,Parry R,Avumegah MS,Isaacs A,Lo MW,Miranda-Chacon Z,Bradshaw D,Salinas-Rebolledo C,Rajapakse NW,Wolvetang EJ,Munro TP,Rojas-Fernandez A,Young PR,Stacey KJ,Khromykh AA,Chappell KJ,Watterson D,Woodruff TM

300-04 was used in Cell Culture to support a possible mechanism of microglial innate immune activation by SARS-CoV-2, which could explain the increased vulnerability to developing neurological symptoms akin to Parkinson's disease in COVID-19 infected individuals, and a potential therapeutic avenue for intervention.

Sat Jul 01 00:00:00 EDT 2023

Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells.

Nature communications

Igarashi N,Miyata K,Loo TM,Chiba M,Hanyu A,Nishio M,Kawasaki H,Zheng H,Toyokuni S,Kon S,Moriyama K,Fujita Y,Takahashi A

300-04 was used in Competition Assay to provide evidence that cellular senescence inhibits cell competition-mediated elimination of oncogenic cells through HGF signaling, suggesting that it may lead to cancer incidence during aging.

Mon Jul 18 00:00:00 EDT 2022

JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.

JCI insight

Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA

300-04 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.

Wed Jun 08 00:00:00 EDT 2022

Inflammation-Driven Regulation of PD-L1 and PD-L2, and Their Cross-Interactions with Protective Soluble TNFα Receptors in Human Triple-Negative Breast Cancer.

Cancers

Baram T,Oren N,Erlichman N,Meshel T,Ben-Baruch A

300-04 was used in Enzyme-linked immunosorbent assay to suggest that in addition to its immune-suppressive activities, PD-L1 may promote disease course in TNBC by inhibiting the protective effects of sTNFR1 and sTNFR2.

Tue Jul 19 00:00:00 EDT 2022

Tumor Cell-Autonomous Pro-Metastatic Activities of PD-L1 in Human Breast Cancer Are Mediated by PD-L1-S283 and Chemokine Axes.

Cancers

Erlichman N,Baram T,Meshel T,Morein D,Da'adoosh B,Ben-Baruch A

300-04 was used in Enzyme-linked immunosorbent assay to investigate the role of WT-PD-L1 in triple-negative breast cancer.

Fri Feb 18 00:00:00 EST 2022

Leukocytes from Patients with Drug-Sensitive and Multidrug-Resistant Tuberculosis Exhibit Distinctive Profiles of Chemokine Receptor Expression and Migration Capacity.

Journal of immunology research

Ocaña-Guzmán R,Téllez-Navarrete NA,Ramón-Luing LA,Herrera I,De Ita M,Carrillo-Alduenda JL,Choreño-Parra JA,Medina-Quero K,Zúñiga J,Chávez-Galán L

Mon Nov 29 00:00:00 EST 2021

Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air-liquid interface model.

Scientific reports

Bluhmki T,Traub S,Müller AK,Bitzer S,Schruf E,Bammert MT,Leist M,Gantner F,Garnett JP,Heilker R

Mon Aug 23 00:00:00 EDT 2021

Continuous Inflammatory Stimulation Leads via Metabolic Plasticity to a Prometastatic Phenotype in Triple-Negative Breast Cancer Cells.

Cells

Morein D,Rubinstein-Achiasaf L,Brayer H,Dorot O,Pichinuk E,Ben-Yaakov H,Meshel T,Pasmanik-Chor M,Ben-Baruch A

300-04 was used in Enzyme-linked immunosorbent assay to demonstrate that a continuous stimulation (~6 weeks) of triple-negative breast tumor cells (TNBC) by the proinflammatory cytokines tumor necrosis factor α (TNFα) + interleukin 1β (IL-1β) changed the expression of hundreds of genes, skewing the cells towards a proinflammatory phenotype which promotes a prometastatic cascade.

Mon May 31 00:00:00 EDT 2021

Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progression.

Scientific reports

Fang WB,Sofia Acevedo D,Smart C,Zinda B,Alissa N,Warren K,Fraga G,Huang LC,Shyr Y,Li W,Xie L,Staggs V,Hong Y,Behbod F,Cheng N

Thu Apr 22 00:00:00 EDT 2021

A novel CXCR4 antagonist counteracts paradoxical generation of cisplatin-induced pro-metastatic niches in lung cancer.

Molecular therapy : the journal of the American Society of Gene Therapy

Bertolini G,Cancila V,Milione M,Lo Russo G,Fortunato O,Zaffaroni N,Tortoreto M,Centonze G,Chiodoni C,Facchinetti F,Pollaci G,Taiè G,Giovinazzo F,Moro M,Camisaschi C,De Toma A,D'Alterio C,Pastorino U,Tripodo C,Scala S,Sozzi G,Roz L

300-04 was used in Cell Culture to reveal that activation of the CXCR4/SDF-1 axis specifically mediates the pro-metastatic effects of cisplatin and suggest CXCR4 blockade as a possible novel combination strategy to control metastatic disease.

Wed Oct 06 00:00:00 EDT 2021

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.

Cell

Blanco-Melo D,Nilsson-Payant BE,Liu WC,Uhl S,Hoagland D,Møller R,Jordan TX,Oishi K,Panis M,Sachs D,Wang TT,Schwartz RE,Lim JK,Albrecht RA,tenOever BR

Thu May 28 00:00:00 EDT 2020

MOSPD2 is a therapeutic target for the treatment of CNS inflammation.

Clinical and experimental immunology

Yacov N,Kafri P,Salem Y,Propheta-Meiran O,Feldman B,Breitbart E,Mendel I

Sat Aug 01 00:00:00 EDT 2020

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides.

Nature communications

Meyrath M,Szpakowska M,Zeiner J,Massotte L,Merz MP,Benkel T,Simon K,Ohnmacht J,Turner JD,Krüger R,Seutin V,Ollert M,Kostenis E,Chevigné A

Fri Jun 19 00:00:00 EDT 2020

Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer's disease risk.

Scientific reports

Murcia JDG,Weinert A,Freitas CMT,Arens DK,Ferrel MN,Grose JH,Ridge PG,Wilson E,Kauwe JSK,Weber KS

Fri May 15 00:00:00 EDT 2020

Cellular census of human fibrosis defines functionally distinct stromal cell types and states.

Nature communications

Layton TB,Williams L,McCann F,Zhang M,Fritzsche M,Colin-York H,Cabrita M,Ng MTH,Feldmann M,Sansom SN,Furniss D,Xie W,Nanchahal J

Tue Jun 02 00:00:00 EDT 2020

An Elvitegravir Nanoformulation Crosses the Blood-Brain Barrier and Suppresses HIV-1 Replication in Microglia.

Viruses

Gong Y,Zhi K,Nagesh PKB,Sinha N,Chowdhury P,Chen H,Gorantla S,Yallapu MM,Kumar S

300-04 was used in In vitro experiments to investigate ART treatment of HIV-1.

Wed May 20 00:00:00 EDT 2020

Development of a miniaturized 96-Transwell air-liquid interface human small airway epithelial model.

Scientific reports

Bluhmki T,Bitzer S,Gindele JA,Schruf E,Kiechle T,Webster M,Schymeinsky J,Ries R,Gantner F,Bischoff D,Garnett J,Heilker R

Mon Aug 03 00:00:00 EDT 2020

Direct Targeting of CREB1 with Imperatorin Inhibits TGFβ2-ERK Signaling to Suppress Esophageal Cancer Metastasis.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Xu WW,Huang ZH,Liao L,Zhang QH,Li JQ,Zheng CC,He Y,Luo TT,Wang Y,Hu HF,Zuo Q,Chen WY,Yang QS,Zhao JF,Qin YR,Xu LY,Li EM,Liao HX,Li B,He QY

Sat Aug 01 00:00:00 EDT 2020

Role of ALDH1A1 and HTRA2 expression in CCL2/CCR2-mediated breast cancer cell growth and invasion.

Biology open

Hu Q,Myers M,Fang W,Yao M,Brummer G,Hawj J,Smart C,Berkland C,Cheng N

300-04 was used in In vitro experiments to investigate the role and mechanisms of CCL2/CCR2 signaling on cell growth and invasion of breast cancer cells.

Fri Jun 28 00:00:00 EDT 2019

Chemokines as the modulators of endometrial epithelial cells remodelling.

Scientific reports

Złotkowska A,Andronowska A

Tue Sep 10 00:00:00 EDT 2019

Chemokines as the modulators of endometrial epithelial cells remodelling.

Scientific reports

Złotkowska A,Andronowska A

Tue Sep 10 00:00:00 EDT 2019

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer.

Frontiers in immunology

Liubomirski Y,Lerrer S,Meshel T,Rubinstein-Achiasaf L,Morein D,Wiemann S,Körner C,Ben-Baruch A

300-04 was used in Enzyme-linked immunosorbent assay to study the impact of tumor-stroma-inflammation networks on pro-metastatic phenotypes in triple-negative breast cancer (TNBC) to identify a novel tumor-stroma-inflammation networks that may promote TNBC aggressiveness by increasing the pro-malignancy potential of the TME and of the tumor cells themselves, and reveal key roles for CXCL8 in mediating these metastasis-promoting activities.

Mon Aug 10 00:00:00 EDT 2020

A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins.

The Journal of biological chemistry

Lee AW,Deruaz M,Lynch C,Davies G,Singh K,Alenazi Y,Eaton JRO,Kawamura A,Shaw J,Proudfoot AEI,Dias JM,Bhattacharya S

Fri Jul 19 00:00:00 EDT 2019

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics.

Molecular & cellular proteomics : MCP

Zhang HE,Hamson EJ,Koczorowska MM,Tholen S,Chowdhury S,Bailey CG,Lay AJ,Twigg SM,Lee Q,Roediger B,Biniossek ML,O'Rourke MB,McCaughan GW,Keane FM,Schilling O,Gorrell MD

Tue Jan 01 00:00:00 EST 2019

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics.

Molecular & cellular proteomics : MCP

Zhang HE,Hamson EJ,Koczorowska MM,Tholen S,Chowdhury S,Bailey CG,Lay AJ,Twigg SM,Lee Q,Roediger B,Biniossek ML,O'Rourke MB,McCaughan GW,Keane FM,Schilling O,Gorrell MD

Tue Jan 01 00:00:00 EST 2019

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics.

Molecular & cellular proteomics : MCP

Zhang HE,Hamson EJ,Koczorowska MM,Tholen S,Chowdhury S,Bailey CG,Lay AJ,Twigg SM,Lee Q,Roediger B,Biniossek ML,O'Rourke MB,McCaughan GW,Keane FM,Schilling O,Gorrell MD

Tue Jan 01 00:00:00 EST 2019

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.

Cell

Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E

300-04 was used in In vitro experiments to report here an unexpected finding that macrophages after antibody-dependent cellular cytotoxicity inhibit NK cell-mediated antibody-dependent cellular cytotoxicity and T cell-mediated cytotoxicity in breast cancers and lymphomas.

Thu Oct 04 00:00:00 EDT 2018

Secreted Giardia intestinalis cysteine proteases disrupt intestinal epithelial cell junctional complexes and degrade chemokines.

Virulence

Liu J,Ma'ayeh S,Peirasmaki D,Lundström-Stadelmann B,Hellman L,Svärd SG

300-04 was used in In vitro experiments to characterise the role of the three main cysteine proteases secreted by Giardia intestinalis in the development of Giardiasis.

Mon Dec 31 00:00:00 EST 2018

Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35.

Journal of immunology (Baltimore, Md. : 1950)

Binti Mohd Amir NAS,Mackenzie AE,Jenkins L,Boustani K,Hillier MC,Tsuchiya T,Milligan G,Pease JE

Sun Jul 15 00:00:00 EDT 2018

Evidence for the Existence of a CXCL17 Receptor Distinct from GPR35.

Journal of immunology (Baltimore, Md. : 1950)

Binti Mohd Amir NAS,Mackenzie AE,Jenkins L,Boustani K,Hillier MC,Tsuchiya T,Milligan G,Pease JE

Sun Jul 15 00:00:00 EDT 2018

Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.

Scientific reports

Alenazi Y,Singh K,Davies G,Eaton JRO,Elders P,Kawamura A,Bhattacharya S

Fri Apr 20 00:00:00 EDT 2018

CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration.

Scientific reports

Fox JM,Kausar F,Day A,Osborne M,Hussain K,Mueller A,Lin J,Tsuchiya T,Kanegasaki S,Pease JE

Thu Jun 21 00:00:00 EDT 2018

Co-Inflammatory Roles of TGFβ1 in the Presence of TNFα Drive a Pro-inflammatory Fate in Mesenchymal Stem Cells.

Frontiers in immunology

Lerrer S,Liubomirski Y,Bott A,Abnaof K,Oren N,Yousaf A,Körner C,Meshel T,Wiemann S,Ben-Baruch A

300-04 was used in Enzyme-linked immunosorbent assay to demonstrate a TNFα + TGFβ1-driven pro-inflammatory fate in MSCs, identify specific molecular mechanisms involved, and propose that TNFα + TGFβ1-stimulated MSCs influence the tumor niche.

Wed Nov 20 00:00:00 EST 2019

Synthesis and biological evaluation of chemokine receptor ligands with 2-benzazepine scaffold.

European journal of medicinal chemistry

Thum S,Kokornaczyk AK,Seki T,De Maria M,Ortiz Zacarias NV,de Vries H,Weiss C,Koch M,Schepmann D,Kitamura M,Tschammer N,Heitman LH,Junker A,Wünsch B

300-04 was used in Cell Culture to offer new insights into ligand recognition by CCR2 and CCR5 receptors.

Fri Jul 28 00:00:00 EDT 2017

The Role of Shed PrP^c in the Neuropathogenesis of HIV Infection.

Journal of immunology (Baltimore, Md. : 1950)

Megra BW,Eugenin EA,Berman JW

Sat Jul 01 00:00:00 EDT 2017

Continuous Delivery of Neutralizing Antibodies Elevate CCL2 Levels in Mice Bearing MCF10CA1d Breast Tumor Xenografts.

Translational oncology

Yao M,Smart C,Hu Q,Cheng N

300-04 was used in Enzyme-linked immunosorbent assay to evaluate the effectiveness of human-specific neutralising antibodies targeting the C-C motif chemokine ligand 2 in breast cancer.

Sun Oct 01 00:00:00 EDT 2017

A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.

Scientific reports

Zhang Y,Wu Y,Qi H,Xiao J,Gong H,Zhang Y,Xu E,Li S,Ma D,Wang Y,Li W,Shen H

Wed Nov 08 00:00:00 EST 2017

Two glycosaminoglycan-binding domains of the mouse cytomegalovirus-encoded chemokine MCK-2 are critical for oligomerization of the full-length protein.

The Journal of biological chemistry

Pontejo SM,Murphy PM

Fri Jun 09 00:00:00 EDT 2017

Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.

Scientific reports

Singh K,Davies G,Alenazi Y,Eaton JRO,Kawamura A,Bhattacharya S

Tue Jun 27 00:00:00 EDT 2017

Monocytes from patients with Primary Ciliary Dyskinesia show enhanced inflammatory properties and produce higher levels of pro-inflammatory cytokines.

Scientific reports

Cockx M,Gouwy M,Ruytinx P,Lodewijckx I,Van Hout A,Knoops S,Pörtner N,Ronsse I,Vanbrabant L,Godding V,De Boeck K,Van Damme J,Boon M,Struyf S

Tue Nov 07 00:00:00 EST 2017

Monocytes from patients with Primary Ciliary Dyskinesia show enhanced inflammatory properties and produce higher levels of pro-inflammatory cytokines.

Scientific reports

Cockx M,Gouwy M,Ruytinx P,Lodewijckx I,Van Hout A,Knoops S,Pörtner N,Ronsse I,Vanbrabant L,Godding V,De Boeck K,Van Damme J,Boon M,Struyf S

Tue Nov 07 00:00:00 EST 2017

M-sec regulates polarized secretion of inflammatory endothelial chemokines and facilitates CCL2-mediated lymphocyte transendothelial migration.

Journal of leukocyte biology

Barzilai S,Blecher-Gonen R,Barnett-Itzhaki Z,Zauberman A,Lebel-Haziv Y,Amit I,Alon R

300-04 was used in Enzyme-linked immunosorbent assay to the first evidence of a novel inflammation-inducible machinery that regulates polarized secretion of endothelial CCL2 and other inflammatory chemokines and cytokines into basolateral endothelial compartments and facilitates the ability of endothelial CCL2 to promote T cell transendothelial migration.

Wed Jun 01 00:00:00 EDT 2016

Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells.

Stem cells (Dayton, Ohio)

Tuccitto A,Tazzari M,Beretta V,Rini F,Miranda C,Greco A,Santinami M,Patuzzo R,Vergani B,Villa A,Manenti G,Cleris L,Giardiello D,Alison M,Rivoltini L,Castelli C,Perego M

Sat Oct 01 00:00:00 EDT 2016

Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.

Journal of immunology (Baltimore, Md. : 1950)

Michlmayr D,Bardina SV,Rodriguez CA,Pletnev AG,Lim JK

Wed Jun 01 00:00:00 EDT 2016

Functional Langerinhigh-Expressing Langerhans-like Cells Can Arise from CD14highCD16- Human Blood Monocytes in Serum-Free Condition.

Journal of immunology (Baltimore, Md. : 1950)

Picarda G,Chéneau C,Humbert JM,Bériou G,Pilet P,Martin J,Duteille F,Perrot P,Bellier-Waast F,Heslan M,Haspot F,Guillon F,Josien R,Halary FA

Sun May 01 00:00:00 EDT 2016

Cytokine-like 1 Chemoattracts Monocytes/Macrophages via CCR2.

Journal of immunology (Baltimore, Md. : 1950)

Wang X,Li T,Wang W,Yuan W,Liu H,Cheng Y,Wang P,Zhang Y,Han W

Sun May 15 00:00:00 EDT 2016

Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytes to chemokine CX3CL1.

Scientific reports

Hermand P,Cicéron L,Pionneau C,Vaquero C,Combadière C,Deterre P

Thu Sep 22 00:00:00 EDT 2016

Plasmodium falciparum proteins involved in cytoadherence of infected erythrocytes to chemokine CX3CL1.

Scientific reports

Hermand P,Cicéron L,Pionneau C,Vaquero C,Combadière C,Deterre P

Thu Sep 22 00:00:00 EDT 2016

Chemical dampening of Ly6C(hi) monocytes in the periphery produces anti-depressant effects in mice.

Scientific reports

Zheng X,Ma S,Kang A,Wu M,Wang L,Wang Q,Wang G,Hao H

Tue Jan 19 00:00:00 EST 2016

Monocyte-derived inflammatory Langerhans cells and dermal dendritic cells mediate psoriasis-like inflammation.

Nature communications

Singh TP,Zhang HH,Borek I,Wolf P,Hedrick MN,Singh SP,Kelsall BL,Clausen BE,Farber JM

Fri Dec 16 00:00:00 EST 2016

The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5.

Scientific reports

Lessel D,Muhammad T,Casar Tena T,Moepps B,Burkhalter MD,Hitz MP,Toka O,Rentzsch A,Schubert S,Schalinski A,Bauer UM,Kubisch C,Ware SM,Philipp M

Tue Sep 13 00:00:00 EDT 2016

Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering macrophage polarity.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Matsubara K,Matsushita Y,Sakai K,Kano F,Kondo M,Noda M,Hashimoto N,Imagama S,Ishiguro N,Suzumura A,Ueda M,Furukawa K,Yamamoto A

300-04 was used in Immunohistochemistry to study how the conditioned serum-free medium (CM) from SHEDs, administered intrathecally into rat injured spinal cord during the acute postinjury period, causes functional recovery as the combination of MCP-1 and ED-Siglec-9 repairs the SCI through anti-inflammatory M2-like macrophage induction.

Wed Feb 11 00:00:00 EST 2015

Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.

Journal of immunology (Baltimore, Md. : 1950)

Lourenco S,Teixeira VH,Kalber T,Jose RJ,Floto RA,Janes SM

Wed Apr 01 00:00:00 EDT 2015

The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells.

Journal of immunology (Baltimore, Md. : 1950)

Mukovozov I,Huang YW,Zhang Q,Liu GY,Siu A,Sokolskyy Y,Patel S,Hyduk SJ,Kutryk MJ,Cybulsky MI,Robinson LA

Thu Oct 01 00:00:00 EDT 2015

The Neurorepellent Slit2 Inhibits Postadhesion Stabilization of Monocytes Tethered to Vascular Endothelial Cells.

Journal of immunology (Baltimore, Md. : 1950)

Mukovozov I,Huang YW,Zhang Q,Liu GY,Siu A,Sokolskyy Y,Patel S,Hyduk SJ,Kutryk MJ,Cybulsky MI,Robinson LA

Thu Oct 01 00:00:00 EDT 2015

MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment.

Nature communications

Riesenberg S,Groetchen A,Siddaway R,Bald T,Reinhardt J,Smorra D,Kohlmeyer J,Renn M,Phung B,Aymans P,Schmidt T,Hornung V,Davidson I,Goding CR,Jönsson G,Landsberg J,Tüting T,Hölzel M

Wed Nov 04 00:00:00 EST 2015

CX3CR1 deficiency promotes muscle repair and regeneration by enhancing macrophage ApoE production.

Nature communications

Arnold L,Perrin H,de Chanville CB,Saclier M,Hermand P,Poupel L,Guyon E,Licata F,Carpentier W,Vilar J,Mounier R,Chazaud B,Benhabiles N,Boissonnas A,Combadiere B,Combadiere C

Thu Dec 03 00:00:00 EST 2015

A positive feedback loop between mesenchymal-like cancer cells and macrophages is essential to breast cancer metastasis.

Cancer cell

Su S,Liu Q,Chen J,Chen J,Chen F,He C,Huang D,Wu W,Lin L,Huang W,Zhang J,Cui X,Zheng F,Li H,Yao H,Su F,Song E

Mon May 12 00:00:00 EDT 2014

Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis.

Proceedings of the National Academy of Sciences of the United States of America

Gobbetti T,Coldewey SM,Chen J,McArthur S,le Faouder P,Cenac N,Flower RJ,Thiemermann C,Perretti M

Tue Dec 30 00:00:00 EST 2014

Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes.

Journal of immunology (Baltimore, Md. : 1950)

Ford LB,Cerovic V,Milling SW,Graham GJ,Hansell CA,Nibbs RJ

Tue Jul 01 00:00:00 EDT 2014

Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1.

Journal of immunology (Baltimore, Md. : 1950)

Bednar F,Song C,Bardi G,Cornwell W,Rogers TJ

Sun Jun 01 00:00:00 EDT 2014

PC3-secreted microprotein is a novel chemoattractant protein and functions as a high-affinity ligand for CC chemokine receptor 2.

Journal of immunology (Baltimore, Md. : 1950)

Pei X,Sun Q,Zhang Y,Wang P,Peng X,Guo C,Xu E,Zheng Y,Mo X,Ma J,Chen D,Zhang Y,Zhang Y,Song Q,Guo S,Shi T,Zhang Z,Ma D,Wang Y

Sat Feb 15 00:00:00 EST 2014

Shear flow affects selective monocyte recruitment into MCP-1-loaded scaffolds.

Journal of cellular and molecular medicine

Smits AI,Ballotta V,Driessen-Mol A,Bouten CV,Baaijens FP

Sat Nov 01 00:00:00 EDT 2014

Breast cancer: coordinated regulation of CCL2 secretion by intracellular glycosaminoglycans and chemokine motifs.

Neoplasia (New York, N.Y.)

Lebel-Haziv Y,Meshel T,Soria G,Yeheskel A,Mamon E,Ben-Baruch A

300-04 was used in Enzyme-linked immunosorbent assay to propose that targeting these chemokine regions may lead to reduced secretion of CCL2 by breast cancer cells (and potentially also by other malignant cells).

Mon Sep 01 00:00:00 EDT 2014

The inflammatory cytokine TNFα cooperates with Ras in elevating metastasis and turns WT-Ras to a tumor-promoting entity in MCF-7 cells.

BMC cancer

Leibovich-Rivkin T,Liubomirski Y,Meshel T,Abashidze A,Brisker D,Solomon H,Rotter V,Weil M,Ben-Baruch A

300-04 was used in Enzyme-linked immunosorbent assay to determine the relative contribution of two processes to breast cancer progression: (1) Intrinsic events, such as activation of the Ras pathway and down-regulation of p53; (2) The inflammatory cytokines TNFα and IL-1β, shown in our published studies to be highly expressed in tumors of >80% of breast cancer patients with recurrent disease.

Thu Mar 06 00:00:00 EST 2014

CX3CR1 reduces Ly6Chigh-monocyte motility within and release from the bone marrow after chemotherapy in mice.

Blood

Jacquelin S,Licata F,Dorgham K,Hermand P,Poupel L,Guyon E,Deterre P,Hume DA,Combadière C,Boissonnas A

Thu Aug 01 00:00:00 EDT 2013

Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.

Journal of immunology (Baltimore, Md. : 1950)

Través PG,Pimentel-Santillana M,Carrasquero LM,Pérez-Sen R,Delicado EG,Luque A,Izquierdo M,Martín-Sanz P,Miras-Portugal MT,Boscá L

Mon Apr 15 00:00:00 EDT 2013

Evidence for a functional thymic stromal lymphopoietin signaling axis in fibrotic lung disease.

Journal of immunology (Baltimore, Md. : 1950)

Datta A,Alexander R,Sulikowski MG,Nicholson AG,Maher TM,Scotton CJ,Chambers RC

Fri Nov 01 00:00:00 EDT 2013

Protective role of the inflammatory CCR2/CCL2 chemokine pathway through recruitment of type 1 cytotoxic γδ T lymphocytes to tumor beds.

Journal of immunology (Baltimore, Md. : 1950)

Lança T,Costa MF,Gonçalves-Sousa N,Rei M,Grosso AR,Penido C,Silva-Santos B

Sat Jun 15 00:00:00 EDT 2013

Progression of luminal breast tumors is promoted by ménage à trois between the inflammatory cytokine TNFα and the hormonal and growth-supporting arms of the tumor microenvironment.

Mediators of inflammation

Weitzenfeld P,Meron N,Leibovich-Rivkin T,Meshel T,Ben-Baruch A

300-04 was used in Enzyme-linked immunosorbent assay to indicate that TNF α can turn into a strong prometastatic factor, suggesting a paradigm shift in which clinically approved inhibitors of TNFα would be applied in breast cancer therapy.

Thu Jun 05 00:00:00 EDT 2014

Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.

PloS one

Asai H,Fujiwara H,An J,Ochi T,Miyazaki Y,Nagai K,Okamoto S,Mineno J,Kuzushima K,Shiku H,Inoue H,Yasukawa M

Tue Aug 13 00:00:00 EDT 2013

Activation of thromboxane A2 receptor (TP) increases the expression of monocyte chemoattractant protein -1 (MCP-1)/chemokine (C-C motif) ligand 2 (CCL2) and recruits macrophages to promote invasion of lung cancer cells.

PloS one

Li X,Tai HH

Wed Jul 24 00:00:00 EDT 2013

Inflammatory factors of the tumor microenvironment induce plasticity in nontransformed breast epithelial cells: EMT, invasion, and collapse of normally organized breast textures.

Neoplasia (New York, N.Y.)

Leibovich-Rivkin T,Liubomirski Y,Bernstein B,Meshel T,Ben-Baruch A

300-04 was used in Enzyme-linked immunosorbent assay to reveal novel pathways through which the inflammatory microenvironment may contribute to relapsed disease in breast cancer.

Sun Dec 01 00:00:00 EST 2013

Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function.

The Journal of biological chemistry

Blanchetot C,Verzijl D,Mujić-Delić A,Bosch L,Rem L,Leurs R,Verrips CT,Saunders M,de Haard H,Smit MJ

Fri Aug 30 00:00:00 EDT 2013

A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer.

PloS one

Curtis VF,Wang H,Yang P,McLendon RE,Li X,Zhou QY,Wang XF

Fri Jul 26 00:00:00 EDT 2013

Posttraumatic invasion of monocytes across the blood-cerebrospinal fluid barrier.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Szmydynger-Chodobska J,Strazielle N,Gandy JR,Keefe TH,Zink BJ,Ghersi-Egea JF,Chodobski A

Sun Jan 01 00:00:00 EST 2012

Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.

Journal of immunology (Baltimore, Md. : 1950)

Swanson CD,Akama-Garren EH,Stein EA,Petralia JD,Ruiz PJ,Edalati A,Lindstrom TM,Robinson WH

Sun Apr 01 00:00:00 EDT 2012

Reduced degradation of the chemokine MCP-3 by matrix metalloproteinase-2 exacerbates myocardial inflammation in experimental viral cardiomyopathy.

Circulation

Westermann D,Savvatis K,Lindner D,Zietsch C,Becher PM,Hammer E,Heimesaat MM,Bereswill S,Völker U,Escher F,Riad A,Plendl J,Klingel K,Poller W,Schultheiss HP,Tschöpe C

Tue Nov 08 00:00:00 EST 2011

MMP-1 drives immunopathology in human tuberculosis and transgenic mice.

The Journal of clinical investigation

Elkington P,Shiomi T,Breen R,Nuttall RK,Ugarte-Gil CA,Walker NF,Saraiva L,Pedersen B,Mauri F,Lipman M,Edwards DR,Robertson BD,D'Armiento J,Friedland JS

Sun May 01 00:00:00 EDT 2011

Leptin enhances survival and induces migration, degranulation, and cytokine synthesis of human basophils.

Journal of immunology (Baltimore, Md. : 1950)

Suzukawa M,Nagase H,Ogahara I,Han K,Tashimo H,Shibui A,Koketsu R,Nakae S,Yamaguchi M,Ohta K

Sun May 01 00:00:00 EDT 2011

Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection.

Journal of immunology (Baltimore, Md. : 1950)

Cross SA,Cook DR,Chi AW,Vance PJ,Kolson LL,Wong BJ,Jordan-Sciutto KL,Kolson DL

Tue Nov 15 00:00:00 EST 2011

Chemokine (C-C motif) ligand 2 mediates direct and indirect fibrotic responses in human and murine cultured fibrocytes.

Fibrogenesis & tissue repair

Ekert JE,Murray LA,Das AM,Sheng H,Giles-Komar J,Rycyzyn MA

Wed Oct 19 00:00:00 EDT 2011

From SOMAmer-based biomarker discovery to diagnostic and clinical applications: a SOMAmer-based, streamlined multiplex proteomic assay.

PloS one

Kraemer S,Vaught JD,Bock C,Gold L,Katilius E,Keeney TR,Kim N,Saccomano NA,Wilcox SK,Zichi D,Sanders GM

Fri Feb 17 00:00:00 EST 2012

Host chemokines bind to Staphylococcus aureus and stimulate protein A release.

The Journal of biological chemistry

Yung SC,Parenti D,Murphy PM

Fri Feb 18 00:00:00 EST 2011

The CD157-integrin partnership controls transendothelial migration and adhesion of human monocytes.

The Journal of biological chemistry

Lo Buono N,Parrotta R,Morone S,Bovino P,Nacci G,Ortolan E,Horenstein AL,Inzhutova A,Ferrero E,Funaro A

Fri May 27 00:00:00 EDT 2011

Duffy antigen receptor for chemokines mediates chemokine endocytosis through a macropinocytosis-like process in endothelial cells.

PloS one

Zhao Y,Mangalmurti NS,Xiong Z,Prakash B,Guo F,Stolz DB,Lee JS

Mon May 21 00:00:00 EDT 2012

Anaesthetic impairment of immune function is mediated via GABA(A) receptors.

PloS one

Wheeler DW,Thompson AJ,Corletto F,Reckless J,Loke JC,Lapaque N,Grant AJ,Mastroeni P,Grainger DJ,Padgett CL,O'Brien JA,Miller NG,Trowsdale J,Lummis SC,Menon DK,Beech JS

Thu Feb 24 00:00:00 EST 2011

Microparticles from apoptotic platelets promote resident macrophage differentiation.

Cell death & disease

Vasina EM,Cauwenberghs S,Feijge MA,Heemskerk JW,Weber C,Koenen RR

Thu Sep 29 00:00:00 EDT 2011

Allosteric and orthosteric sites in CC chemokine receptor (CCR5), a chimeric receptor approach.

The Journal of biological chemistry

Thiele S,Steen A,Jensen PC,Mokrosinski J,Frimurer TM,Rosenkilde MM

Fri Oct 28 00:00:00 EDT 2011

Evidence for a cross-talk between human neutrophils and Th17 cells.

Blood

Pelletier M,Maggi L,Micheletti A,Lazzeri E,Tamassia N,Costantini C,Cosmi L,Lunardi C,Annunziato F,Romagnani S,Cassatella MA

Thu Jan 14 00:00:00 EST 2010

Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection.

PLoS pathogens

Crawford MA,Burdick MD,Glomski IJ,Boyer AE,Barr JR,Mehrad B,Strieter RM,Hughes MA

Thu Nov 18 00:00:00 EST 2010

Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing.

Stem cells (Dayton, Ohio)

Zhang QZ,Su WR,Shi SH,Wilder-Smith P,Xiang AP,Wong A,Nguyen AL,Kwon CW,Le AD

Fri Oct 01 00:00:00 EDT 2010

CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response.

Journal of immunology (Baltimore, Md. : 1950)

Zhang HH,Song K,Rabin RL,Hill BJ,Perfetto SP,Roederer M,Douek DC,Siegel RM,Farber JM

Wed Dec 01 00:00:00 EST 2010

Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.

Journal of immunology (Baltimore, Md. : 1950)

Röhrl J,Yang D,Oppenheim JJ,Hehlgans T

Tue Jun 15 00:00:00 EDT 2010

Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation.

Journal of immunology (Baltimore, Md. : 1950)

Rius C,Abu-Taha M,Hermenegildo C,Piqueras L,Cerda-Nicolas JM,Issekutz AC,Estañ L,Cortijo J,Morcillo EJ,Orallo F,Sanz MJ

Wed Sep 15 00:00:00 EDT 2010

Trans- but not cis-resveratrol impairs angiotensin-II-mediated vascular inflammation through inhibition of NF-κB activation and peroxisome proliferator-activated receptor-gamma upregulation.

Journal of immunology (Baltimore, Md. : 1950)

Rius C,Abu-Taha M,Hermenegildo C,Piqueras L,Cerda-Nicolas JM,Issekutz AC,Estañ L,Cortijo J,Morcillo EJ,Orallo F,Sanz MJ

Wed Sep 15 00:00:00 EDT 2010

M2b monocytes predominated in peripheral blood of severely burned patients.

Journal of immunology (Baltimore, Md. : 1950)

Kobayashi M,Jeschke MG,Shigematsu K,Asai A,Yoshida S,Herndon DN,Suzuki F

Wed Dec 15 00:00:00 EST 2010

Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients.

Journal of immunology (Baltimore, Md. : 1950)

Madigan J,Freeman DJ,Menzies F,Forrow S,Nelson SM,Young A,Sharkey A,Moffett A,Graham GJ,Greer IA,Rot A,Nibbs RJ

Mon Mar 15 00:00:00 EDT 2010

Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.

Molecular pain

Chen T,Koga K,Li XY,Zhuo M

Fri Apr 09 00:00:00 EDT 2010

Filamin a binds to CCR2B and regulates its internalization.

PloS one

Minsaas L,Planagumà J,Madziva M,Krakstad BF,Masià-Balagué M,Katz AA,Aragay AM

Tue Aug 17 00:00:00 EDT 2010

Rationally evolving MCP-1/CCL2 into a decoy protein with potent anti-inflammatory activity in vivo.

The Journal of biological chemistry

Piccinini AM,Knebl K,Rek A,Wildner G,Diedrichs-Möhring M,Kungl AJ

Fri Mar 19 00:00:00 EDT 2010

Transcriptome analysis of monocyte-HIV interactions.

Retrovirology

Van den Bergh R,Florence E,Vlieghe E,Boonefaes T,Grooten J,Houthuys E,Tran HT,Gali Y,De Baetselier P,Vanham G,Raes G

Mon Jun 14 00:00:00 EDT 2010

An antimicrobial peptide regulates tumor-associated macrophage trafficking via the chemokine receptor CCR2, a model for tumorigenesis.

PloS one

Jin G,Kawsar HI,Hirsch SA,Zeng C,Jia X,Feng Z,Ghosh SK,Zheng QY,Zhou A,McIntyre TM,Weinberg A

Tue Jun 08 00:00:00 EDT 2010

Dynamic interaction networks in a hierarchically organized tissue.

Molecular systems biology

Kirouac DC,Ito C,Csaszar E,Roch A,Yu M,Sykes EA,Bader GD,Zandstra PW

Tue Oct 05 00:00:00 EDT 2010

Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance.

PLoS genetics

Mauer J,Chaurasia B,Plum L,Quast T,Hampel B,Blüher M,Kolanus W,Kahn CR,Brüning JC

Thu May 06 00:00:00 EDT 2010

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice.

Nature medicine

Koenen RR,von Hundelshausen P,Nesmelova IV,Zernecke A,Liehn EA,Sarabi A,Kramp BK,Piccinini AM,Paludan SR,Kowalska MA,Kungl AJ,Hackeng TM,Mayo KH,Weber C

Thu Jan 01 00:00:00 EST 2009

CC chemokine ligand 2 down-modulation by selected Toll-like receptor agonist combinations contributes to T helper 1 polarization in human dendritic cells.

Blood

Del Cornò M,Michienzi A,Masotti A,Da Sacco L,Bottazzo GF,Belardelli F,Gessani S

Thu Jul 23 00:00:00 EDT 2009

Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation.

Blood

Mangalmurti NS,Xiong Z,Hulver M,Ranganathan M,Liu XH,Oriss T,Fitzpatrick M,Rubin M,Triulzi D,Choi A,Lee JS

Thu Jan 29 00:00:00 EST 2009

Inhibitory effect of glycyrrhizin on the neutrophil-dependent increase of R5 HIV replication in cultures of macrophages.

Immunology and cell biology

Yoshida T,Kobayashi M,Li XD,Pollard RB,Suzuki F

Thu Oct 01 00:00:00 EDT 2009

Menopause and ovariectomy cause a low grade of systemic inflammation that may be prevented by chronic treatment with low doses of estrogen or losartan.

Journal of immunology (Baltimore, Md. : 1950)

Abu-Taha M,Rius C,Hermenegildo C,Noguera I,Cerda-Nicolas JM,Issekutz AC,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

Wed Jul 15 00:00:00 EDT 2009

A novel recombinant fusion protein encoding a 20-amino acid residue of the third extracellular (E3) domain of CCR2 neutralizes the biological activity of CCL2.

Journal of immunology (Baltimore, Md. : 1950)

Izhak L,Wildbaum G,Zohar Y,Anunu R,Klapper L,Elkeles A,Seagal J,Yefenof E,Ayalon-Soffer M,Karin N

Wed Jul 01 00:00:00 EDT 2009

Streptococcus agalactiae CspA is a serine protease that inactivates chemokines.

Journal of bacteriology

Bryan JD,Shelver DW

Sun Mar 01 00:00:00 EST 2009

Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions.

The Journal of biological chemistry

Barth MC,Ahluwalia N,Anderson TJ,Hardy GJ,Sinha S,Alvarez-Cardona JA,Pruitt IE,Rhee EP,Colvin RA,Gerszten RE

Fri Jul 17 00:00:00 EDT 2009

Chemokine (C-C motif) ligand 2 engages CCR2+ stromal cells of monocytic origin to promote breast cancer metastasis to lung and bone.

The Journal of biological chemistry

Lu X,Kang Y

Fri Oct 16 00:00:00 EDT 2009

Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.

Blood

Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA

Sat Nov 01 00:00:00 EDT 2008

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment.

Proceedings of the National Academy of Sciences of the United States of America

Weber C,Kraemer S,Drechsler M,Lue H,Koenen RR,Kapurniotu A,Zernecke A,Bernhagen J

Tue Oct 21 00:00:00 EDT 2008

Modulation of keratinocyte-derived MMP-9 by IL-13: a possible role for the pathogenesis of epidermal inflammation.

The Journal of investigative dermatology

Purwar R,Kraus M,Werfel T,Wittmann M

Tue Jan 01 00:00:00 EST 2008

Structure and function of A41, a vaccinia virus chemokine binding protein.

PLoS pathogens

Bahar MW,Kenyon JC,Putz MM,Abrescia NG,Pease JE,Wise EL,Stuart DI,Smith GL,Grimes JM

Tue Jan 01 00:00:00 EST 2008

IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.

Journal of immunology (Baltimore, Md. : 1950)

Hu Y,Hu X,Boumsell L,Ivashkiv LB

Sun Jun 15 00:00:00 EDT 2008

Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Lim HW,Lee J,Hillsamer P,Kim CH

Tue Jan 01 00:00:00 EST 2008

Signal regulatory protein alpha negatively regulates beta2 integrin-mediated monocyte adhesion, transendothelial migration and phagocytosis.

PloS one

Liu DQ,Li LM,Guo YL,Bai R,Wang C,Bian Z,Zhang CY,Zen K

Mon Sep 29 00:00:00 EDT 2008

A critical role for TNFalpha in the selective attachment of mononuclear leukocytes to angiotensin-II-stimulated arterioles.

Blood

Mateo T,Naim Abu Nabah Y,Losada M,Estellés R,Company C,Bedrina B,Cerdá-Nicolás JM,Poole S,Jose PJ,Cortijo J,Morcillo EJ,Sanz MJ

Sat Sep 15 00:00:00 EDT 2007

CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration.

Arteriosclerosis, thrombosis, and vascular biology

Abu Nabah YN,Losada M,Estellés R,Mateo T,Company C,Piqueras L,Lopez-Gines C,Sarau H,Cortijo J,Morcillo EJ,Jose PJ,Sanz MJ

Thu Nov 01 00:00:00 EDT 2007

CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltration.

Arteriosclerosis, thrombosis, and vascular biology

Abu Nabah YN,Losada M,Estellés R,Mateo T,Company C,Piqueras L,Lopez-Gines C,Sarau H,Cortijo J,Morcillo EJ,Jose PJ,Sanz MJ

Thu Nov 01 00:00:00 EDT 2007

Anti-IL-8 autoantibody:IL-8 immune complexes suppress spontaneous apoptosis of neutrophils.

American journal of physiology. Lung cellular and molecular physiology

Fudala R,Krupa A,Matthay MA,Allen TC,Kurdowska AK

Wed Aug 01 00:00:00 EDT 2007

The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.

Stem cells (Dayton, Ohio)

Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J

Sun Jul 01 00:00:00 EDT 2007

Microglial cells from psychologically stressed mice as an accelerator of cerebral cryptococcosis.

Immunology and cell biology

Shimoda M,Jones VC,Kobayashi M,Suzuki F

Fri Dec 01 00:00:00 EST 2006

CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Cappello P,Fraone T,Barberis L,Costa C,Hirsch E,Elia AR,Caorsi C,Musso T,Novelli F,Giovarelli M

Wed Nov 01 00:00:00 EST 2006

Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Lim HW,Broxmeyer HE,Kim CH

Sat Jul 15 00:00:00 EDT 2006

Human herpesvirus 7 open reading frames U12 and U51 encode functional beta-chemokine receptors.

Journal of virology

Tadagaki K,Nakano K,Yamanishi K

Wed Jun 01 00:00:00 EDT 2005

Human tumor antigen MUC1 is chemotactic for immature dendritic cells and elicits maturation but does not promote Th1 type immunity.

Journal of immunology (Baltimore, Md. : 1950)

Carlos CA,Dong HF,Howard OM,Oppenheim JJ,Hanisch FG,Finn OJ

Mon Aug 01 00:00:00 EDT 2005

MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation.

The Journal of biological chemistry

Kim MS,Day CJ,Morrison NA

Fri Apr 22 00:00:00 EDT 2005

Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.

Blood

Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M

Thu Jul 01 00:00:00 EDT 2004

Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.

Blood

Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M

Thu Jul 01 00:00:00 EDT 2004

Enhanced protein profiling arrays with ELISA-based amplification for high-throughput molecular changes of tumor patients' plasma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Huang R,Lin Y,Shi Q,Flowers L,Ramachandran S,Horowitz IR,Parthasarathy S,Huang RP

Thu Jan 15 00:00:00 EST 2004

Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: prevention of reperfusion injury.

Proceedings of the National Academy of Sciences of the United States of America

Bertini R,Allegretti M,Bizzarri C,Moriconi A,Locati M,Zampella G,Cervellera MN,Di Cioccio V,Cesta MC,Galliera E,Martinez FO,Di Bitondo R,Troiani G,Sabbatini V,D'Anniballe G,Anacardio R,Cutrin JC,Cavalieri B,Mainiero F,Strippoli R,Villa P,Di Girolamo M,Martin F,Gentile M,Santoni A,Corda D,Poli G,Mantovani A,Ghezzi P,Colotta F

Tue Aug 10 00:00:00 EDT 2004

Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2.

Journal of immunology (Baltimore, Md. : 1950)

Hartnell A,Heinemann A,Conroy DM,Wait R,Sturm GJ,Caversaccio M,Jose PJ,Williams TJ

Mon Nov 15 00:00:00 EST 2004

Human P-selectin glycoprotein ligand-1 (PSGL-1) interacts with the skin-associated chemokine CCL27 via sulfated tyrosines at the PSGL-1 amino terminus.

The Journal of biological chemistry

Hirata T,Furukawa Y,Yang BG,Hieshima K,Fukuda M,Kannagi R,Yoshie O,Miyasaka M

Fri Dec 10 00:00:00 EST 2004

Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.

The Journal of biological chemistry

Alvarez Arias D,Navenot JM,Zhang WB,Broach J,Peiper SC

Fri Sep 19 00:00:00 EDT 2003

A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.

The Journal of biological chemistry

Sabroe I,Peck MJ,Van Keulen BJ,Jorritsma A,Simmons G,Clapham PR,Williams TJ,Pease JE

Fri Aug 25 00:00:00 EDT 2000

A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.

The Journal of biological chemistry

Sabroe I,Peck MJ,Van Keulen BJ,Jorritsma A,Simmons G,Clapham PR,Williams TJ,Pease JE

Fri Aug 25 00:00:00 EDT 2000

MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions.

Nature

Gerszten RE,Garcia-Zepeda EA,Lim YC,Yoshida M,Ding HA,Gimbrone MA,Luster AD,Luscinskas FW,Rosenzweig A

Thu Apr 22 00:00:00 EDT 1999

Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways.

Journal of immunology (Baltimore, Md. : 1950)

Sabroe I,Hartnell A,Jopling LA,Bel S,Ponath PD,Pease JE,Collins PD,Williams TJ

Mon Mar 01 00:00:00 EST 1999

Chemokines and the arrest of lymphocytes rolling under flow conditions.

Science (New York, N.Y.)

Campbell JJ,Hedrick J,Zlotnik A,Siani MA,Thompson DA,Butcher EC

Fri Jan 16 00:00:00 EST 1998

Chemokine sequestration by viral chemoreceptors as a novel viral escape strategy: withdrawal of chemokines from the environment of cytomegalovirus-infected cells.

The Journal of experimental medicine

Bodaghi B,Jones TR,Zipeto D,Vita C,Sun L,Laurent L,Arenzana-Seisdedos F,Virelizier JL,Michelson S

Mon Sep 07 00:00:00 EDT 1998

HIV-1 envelope gp120 inhibits the monocyte response to chemokines through CD4 signal-dependent chemokine receptor down-regulation.

Journal of immunology (Baltimore, Md. : 1950)

Wang JM,Ueda H,Howard OM,Grimm MC,Chertov O,Gong X,Gong W,Resau JH,Broder CC,Evans G,Arthur LO,Ruscetti FW,Oppenheim JJ

Thu Oct 15 00:00:00 EDT 1998

The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6, and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells.

Journal of immunology (Baltimore, Md. : 1950)

van den Berg RH,Faber-Krol MC,Sim RB,Daha MR

Tue Dec 15 00:00:00 EST 1998

The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6, and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells.

Journal of immunology (Baltimore, Md. : 1950)

van den Berg RH,Faber-Krol MC,Sim RB,Daha MR

Tue Dec 15 00:00:00 EST 1998

The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6, and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells.

Journal of immunology (Baltimore, Md. : 1950)

van den Berg RH,Faber-Krol MC,Sim RB,Daha MR

Tue Dec 15 00:00:00 EST 1998

Type I IFNs enhance the terminal differentiation of dendritic cells.

Journal of immunology (Baltimore, Md. : 1950)

Luft T,Pang KC,Thomas E,Hertzog P,Hart DN,Trapani J,Cebon J

Sat Aug 15 00:00:00 EDT 1998

Identification of single C motif-1/lymphotactin receptor XCR1.

The Journal of biological chemistry

Yoshida T,Imai T,Kakizaki M,Nishimura M,Takagi S,Yoshie O

Fri Jun 26 00:00:00 EDT 1998

Murine monocyte chemoattractant protein (MCP)-5: a novel CC chemokine that is a structural and functional homologue of human MCP-1.

The Journal of experimental medicine

Sarafi MN,Garcia-Zepeda EA,MacLean JA,Charo IF,Luster AD

Mon Jan 06 00:00:00 EST 1997

Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.

The Journal of experimental medicine

Tiffany HL,Lautens LL,Gao JL,Pease J,Locati M,Combadiere C,Modi W,Bonner TI,Murphy PM

Mon Jul 07 00:00:00 EDT 1997

Regulation of the receptor specificity and function of the chemokine RANTES (regulated on activation, normal T cell expressed and secreted) by dipeptidyl peptidase IV (CD26)-mediated cleavage.

The Journal of experimental medicine

Oravecz T,Pall M,Roderiquez G,Gorrell MD,Ditto M,Nguyen NY,Boykins R,Unsworth E,Norcross MA

Mon Dec 01 00:00:00 EST 1997

Cloning and characterization of a specific receptor for the novel CC chemokine MIP-3alpha from lung dendritic cells.

The Journal of experimental medicine

Power CA,Church DJ,Meyer A,Alouani S,Proudfoot AE,Clark-Lewis I,Sozzani S,Mantovani A,Wells TN

Mon Sep 15 00:00:00 EDT 1997

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Cat#

Description

Cond.

Price Bef. VAT

R00002

Recombinant Human TNF alpha Protein

100ug/vial