Mouse GbA (Glucosidase Beta, Acid) Sandwich ELISA Kit Ready-To-Use

Storage Instruction:	The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	3 hrs

Gene Symbol:	Gba1
Gene ID:	14466
Uniprot ID:	GBA1_MOUSE
Immunogen Region:	Ready-To-Use
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity
Post Translational Modifications
Function	Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide. Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers. Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside.
Protein Name	Lysosomal Acid Glucosylceramidase Lysosomal Acid Gcase Acid Beta-Glucosidase Beta-Glucocerebrosidase Cholesterol Glucosyltransferase Sgtase Cholesteryl-Beta-Glucosidase D-Glucosyl-N-Acylsphingosine Glucohydrolase Lysosomal Cholesterol Glycosyltransferase Lysosomal Galactosylceramidase Lysosomal Glycosylceramidase
Database Links	Reactome: R-MMU-1660662
Cellular Localisation	Lysosome Membrane Peripheral Membrane Protein Lumenal Side Interaction With Saposin-C Promotes Membrane ?Association Targeting To Lysosomes Occurs Through An Alternative Mpr-Independent Mechanism Via Scarb2
Alternative ELISA Names	Lysosomal Acid Glucosylceramidase ELISA kit Lysosomal Acid Gcase ELISA kit Acid Beta-Glucosidase ELISA kit Beta-Glucocerebrosidase ELISA kit Cholesterol Glucosyltransferase ELISA kit Sgtase ELISA kit Cholesteryl-Beta-Glucosidase ELISA kit D-Glucosyl-N-Acylsphingosine Glucohydrolase ELISA kit Lysosomal Cholesterol Glycosyltransferase ELISA kit Lysosomal Galactosylceramidase ELISA kit Lysosomal Glycosylceramidase ELISA kit Gba1 ELISA kit Gba ELISA kit
output

Information sourced from Uniprot.org

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