N-acetylcysteine amide

Biological Activity

N-acetylcysteine amide is a membrane penetrating antioxidant with antiinflamatory activity through regulation of activation of NF-κB and HIF-1α as well as modulation of ROS. The compound readily crosses cell membranes, replenishes intracellular GSH, and defends the cell from oxidative stress. In contrast to DTT, AD4 is able to directly reduce intracellularl GSSG to GSH without the involvement of glutathione peroxidase. Such direct thiol exchange might have a protective effect. This compound has a potential in research and exploration for treatment of neurodegeneration, radiation exposure, and other oxidation-mediated disorders.

Product Citations

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  Phytomedicine. 2024 Apr 21.

  Dihydrotanshinone I inhibits gallbladder cancer growth by targeting the Keap1-Nrf2 signaling pathway and Nrf2 phosphorylation
  N-acetylcysteine amide purchased from AbMole

Chemical Information

Molecular Weight	162.21
Formula	C5H10N2O2S
CAS Number	38520-57-9
Solubility (25°C)	Water ≥ 90 mg/mL DMSO ≥ 50 mg/mL
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Kristina Xiao Liang, et al. N-acetylcysteine amide ameliorates mitochondrial dysfunction and reduces oxidative stress in hiPSC-derived dopaminergic neurons with POLG mutation

[2] Gokhan Erol, et al. Effects of N-Acetylcysteine and N-Acetylcysteine Amide on Erythrocyte Deformability and Oxidative Stress in a Rat Model of Lower Extremity Ischemia-Reperfusion Injury

[3] Carlos G Reis, et al. Effects of N-acetylcysteine amide on anxiety and stress behavior in zebrafish

[4] Rui He, et al. Pharmacokinetic profile of N-acetylcysteine amide and its main metabolite in mice using new analytical method

[5] K Sunitha, et al. N-Acetylcysteine amide: a derivative to fulfill the promises of N-Acetylcysteine