Physostigmine (salicylate) [57-64-7]
Cat# HY-B1266-100mg
Size : 100mg
Brand : MedChemExpress
Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning.
For research use only. We do not sell to patients.
Physostigmine salicylate Chemical Structure
CAS No. : 57-64-7
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Other Forms of Physostigmine salicylate:
- Physostigmine hemisulfate In-stock
- Physostigmine In-stock
View All Cholinesterase (ChE) Isoform Specific Products:
Description |
Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine salicylate crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning[1][2][3][4]. |
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IC50 & Target |
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In Vivo |
Physostigmine salicylate (Eserine salicylate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Clinical Trial |
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Molecular Weight |
413.47 |
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Formula |
C22H27N3O5 |
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CAS No. |
57-64-7 |
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Appearance |
Solid |
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Color |
White to yellow |
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SMILES |
O=C(O)C1=CC=CC=C1O.O=C(OC2=CC3=C(N(C)[C@]4(22)[C@@]3(C)CCN4C)C=C2)NC |
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Shipping | Room temperature in continental US; may vary elsewhere. |
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Storage |
4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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Solvent & Solubility |
In Vitro:
DMSO : 100 mg/mL (241.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO) H2O : 33.33 mg/mL (80.61 mM; Need ultrasonic) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
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Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Purity & Documentation | |||||||||||||
References |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O / DMSO | 1 mM | 2.4186 mL | 12.0928 mL | 24.1856 mL | 60.4639 mL |
5 mM | 0.4837 mL | 2.4186 mL | 4.8371 mL | 12.0928 mL | |
10 mM | 0.2419 mL | 1.2093 mL | 2.4186 mL | 6.0464 mL | |
15 mM | 0.1612 mL | 0.8062 mL | 1.6124 mL | 4.0309 mL | |
20 mM | 0.1209 mL | 0.6046 mL | 1.2093 mL | 3.0232 mL | |
25 mM | 0.0967 mL | 0.4837 mL | 0.9674 mL | 2.4186 mL | |
30 mM | 0.0806 mL | 0.4031 mL | 0.8062 mL | 2.0155 mL | |
40 mM | 0.0605 mL | 0.3023 mL | 0.6046 mL | 1.5116 mL | |
50 mM | 0.0484 mL | 0.2419 mL | 0.4837 mL | 1.2093 mL | |
60 mM | 0.0403 mL | 0.2015 mL | 0.4031 mL | 1.0077 mL | |
80 mM | 0.0302 mL | 0.1512 mL | 0.3023 mL | 0.7558 mL | |
DMSO | 100 mM | 0.0242 mL | 0.1209 mL | 0.2419 mL | 0.6046 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Physostigmine salicylate Related Classifications
- Neuronal Signaling
- Cholinesterase (ChE)