Recombinant Human IFN-α 1b（E. coli）

Biological Activity

Species: Human
Expression system: E. coli
Purity: SDS-PAGE analysis > 96%, HPLC analysis > 96%
Endotoxin: LAL protein content < 1 EU/μg
Theoretical molecular weight: 19.5 kDa
Storage and stability: Upon receipt, this product remains stable at -70°C or -20°C for up to 6 months. After reconstruction, the product should be stable at 4°C for up to 1 week or at -20°C for up to 3 months. Avoid repeated freeze-thaw cycles



At least 23 different variants of interferon are known. Individual proteins have a molecular mass of 19-26 kDa and are composed of 156-166 and 172 amino acids. All ifn-α isoforms share a common conserved sequence region between amino acid positions 115-151, and the amino acid terminal terminal is variable. The sequences of many ifn-α isoforms differ in only one or two locations. Naturally occurring variations also include proteins that have 10 amino acids truncated at the carboxyl terminus.

Chemical Information

Solubility (25°C)	Reconstitute the lyophilized powder in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
Storage	Powder          -20°C   3 years ;  4°C   2 years In solvent       -80°C   6 months ;  -20°C   1 month

References

[1] Alexandros Stamatopoulos, et al. J Bone Oncol. Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice

[2] Songying Ouyang, et al. J Mol Med (Berl). Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus

[3] Wang-Long Chuang, et al. Intervirology. Treatment of chronic hepatitis C in southern Taiwan

[4] H S Panitch. Mult Scler. Early treatment trials with interferon beta in multiple sclerosis

[5] E C O'Rourke, et al. Mol Cell Biol. Binding of 125I-labeled recombinant beta interferon (IFN-beta Ser17) to human cells