Remdesivir (GS-5734)

Cat# 532401-10mg

Size : 10mg

Brand : US Biological

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532401 Remdesivir (GS-5734)

Clone Type
Polyclonal
Grade
Highly Purified
Shipping Temp
RT
Storage Temp
-20°C

Remdesivir, also known as GS-5734, is an antiviral drug, and a novel nucleotide analog prodrug. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74nM in HAE cells after treatment for 24h. GS-5734 inhibits both epidemic and zoonotic coronaviruses. It was developed by Gilead Sciences as a treatment for filovirus infections such as Ebola virus disease and Marburg virus. Remdesivir share the same core structure with that of GS-441524. Remdesivir may consider as a prodrug of GS-441524.||Remdesivir has been found to show reasonable antiviral activity against more distantly related viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, and MERS-coronavirus. GS-5734 was rapidly pushed through clinical trials due to the 2013–2016 West African Ebola virus epidemic crisis, eventually being used in at least one human patient despite its early development stage at the time. Preliminary results have been promising, and further clinical trials are planned.||Synonyms:|2-Ethylbutyl (2S)-2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate; 2-ethylbutyl ((((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate; GS-5734; Prodrug of GS-441524||CAS Number:|1809249-37-3||Molecular Weight:|602.58||Molecular Formula:|C27H35N6O8P||Appearance:|White to off-white solid||Purity:|≥98%||Elemental Analysis:|C, 53.82; H, 5.85; N, 13.95; O, 21.24; P, 5.14||Solubility:|Soluble in DMSO||Storage and Stability:|Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Applications
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Form
White to off-white solid
Purity
≥98%
References
1: Check Hayden E. Experimental drugs poised for use in Ebola outbreak. Nature. 2018 May;557(7706):475-476. doi: 10.1038/d41586-018-05205-x. PubMed PMID: 29789732.|2: Agostini ML, Andres EL, Sims AC, Graham RL, Sheahan TP, Lu X, Smith EC, Case JB, Feng JY, Jordan R, Ray AS, Cihlar T, Siegel D, Mackman RL, Clarke MO, Baric RS, Denison MR. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18. doi: 10.1128/mBio.00221-18. PubMed PMID: 29511076; PubMed Central PMCID: PMC5844999.|3: Jordan PC, Liu C, Raynaud P, Lo MK, Spiropoulou CF, Symons JA, Beigelman L, Deval J. Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase. PLoS Pathog. 2018 Feb 9;14(2):e1006889. doi: 10.1371/journal.ppat.1006889. eCollection 2018 Feb. PubMed PMID: 29425244; PubMed Central PMCID: PMC5823471.|4: Bixler SL, Duplantier AJ, Bavari S. Discovering Drugs for the Treatment of Ebola Virus. Curr Treat Options Infect Dis. 2017;9(3):299-317. doi: 10.1007/s40506-017-0130-z. Epub 2017 Aug 4. Review. PubMed PMID: 28890666; PubMed Central PMCID: PMC5570806.|5: Sheahan TP, Sims AC, Graham RL, Menachery VD, Gralinski LE, Case JB, Leist SR, Pyrc K, Feng JY, Trantcheva I, Bannister R, Park Y, Babusis D, Clarke MO, Mackman RL, Spahn JE, Palmiotti CA, Siegel D, Ray AS, Cihlar T, Jordan R, Denison MR, Baric RS. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med. 2017 Jun 28;9(396). pii: eaal3653. doi: 10.1126/scitranslmed.aal3653. PubMed PMID: 28659436; PubMed Central PMCID: PMC5567817.