Our RICTOR FISH Probe is designed to detect RICTOR amplifications and deletions. The probe comes labeled in orange, but can be customized to meet your needs.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
Gene Summary
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
Gene Details
Gene Symbol: RICTOR
Gene Name: RPTOR Independent Companion Of MTOR Complex 2
Chromosome: CHR5: 38938021-39074501
Locus: 5p13.1
References
Correlation between immunohistochemistry and RICTOR FISH amplification in small cell lung carcinoma
Small cell lung carcinoma (SCLC) accounts for approximately 15% of all lung cancers and remains a challenging disease to treat, with no significant improvements in the development of targeted therapies. RICTOR is one of the most frequently amplified genes and a potential therapeutic target in SCLC. This study used IHC and Empire Genomics' RICTOR FISH probe to evaluate RICTOR overexpression and gene amplification in 100 SCLC tumors.
Correlation between RICTOR overexpression and amplification in advanced solid tumors
RICTOR amplification is common across many solid tumors, and recent studies point to the gene as a potential targetable alteration. This study used IHC to measure RICTOR protein expression and our RICTOR FISH probe to detect RICTOR amplification in 213 advanced solid tumors. RICTOR was found overexpressed in 47% of tumors, and IHC and FISH results were closely correlated, indicating that RICTOR overexpression is associated with tumor progression.