Stemolecule™ LDN-193189
04-0074 / 04-0074-10 / 04-0074-02
Brand: Stemolecule
LDN193189 is a cell permeable, small molecule inhibitor of bone morphogenetic protein (BMP) type I receptors ALK2 and ALK3.
CAS Number: 1062368-24-4
Alternate Name(s):
- LDN193189
- 4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline hydrochloride
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Product Information
50 = 5nM and 30nM respectively)1. LDN-193189 was derived from structure-activity relationship studies of dorsomorphin and functions primarily through prevention of Smad1, Smad5, and Smad8 phosphorylation1-3. LDN-193189 only weakly inhibits ALK4, ALK5, and ALK71. BMP signaling coordinates developmental patterning and has essential physiological roles in mature organisms4,5. LDN-193189has been used to reduce ectopic ossification in a mouse model of fibrodysplasia ossificans progressiva1. Stemolecule LDN-193189 is a hydrochloride salt.
Discontinued Product Cat. No. 04-0019: Stemolecule LDN-193189 is the suggested replacement for the discontinued product Stemolecule LDN-193189 Free Base (Cat.No. 04-0019). While the free base form was only soluble in chloroform, this salt-based form is soluble in DMSO for your convenience.
04-0074 Specifications Sheet 04-0074-10 Specifications Sheet 04-0074-02 Specifications Sheet
Safety Data Sheets:
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Additional Publications
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