Vcap cells
Cat# C0019001
Size : OneFrozenvial
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Disease:
Prostate cancer
Origin:
Derived from vertebral metastasis
Species:
Homo sapiens
Tissue:
Prostate
Morphology:
Epithelial
Properties:
Adherent
Cytogenic data:
Tumorigenic
Patient:
Male, Caucasian, 59 yrs of age
Medium:
AddexBio-formulated DMEM (C0003-01) + 10% FBS
Subculture:
1:3 to 1:4 using 0.25% trypsin or trypsin/EDTA, 5% CO2; 37°C
Freezing Medium:
Complete culture medium supplemented with 5% (v/v) DMSO
Biosafety Level:
II (cells produce the mouse xenotropic retrovirus Bxv-1)Sterility:
Bacteria: Negative
Yeast: Negative
Mycoplasma: Negative
Pathogens:
HIV: Negative
Hepatitis B: Negative
Hepatitis C: Negative
Protein Expression:
Androgen receptor; cytokeratin-18; p53 antigen; prostate specific antigen (PSA); prostatic acid phosphatase (PAP); Rb proteinIsoenzymes:
DNA Profile (STR):
Amelogenin: X,Y
CSF1PO: 10,12
D13S317: 11,12
D16S539: 9
D5S818: 12
D7S820: 9,12
THO1: 9.3
TPOX: 8,11
vWA: 18,19
Related cells by Organ:
PC-3 cells
VcaP cells
References for VcaP cells:
1. Vyas, H. K., Pal, R., Lohiya, N. K., and Talwar, G. P. A partner monoclonal antibody to Moab 730 kills 100% of DU145 and PC3 androgen-independent cancer cells. J Biosci, 34: 909-916, 2009.
2. Roca, H., Varsos, Z. S., and Pienta, K. J. CCL2 is a negative regulator of AMP-activated protein kinase to sustain mTOR complex-1 activation, survivin expression, and cell survival in human prostate cancer PC3 cells. Neoplasia, 11: 1309-1317, 2009.
3. Olea-Herrero, N., Vara, D., Malagarie-Cazenave, S., and Diaz-Laviada, I. The cannabinoid R+ methanandamide induces IL-6 secretion by prostate cancer PC3 cells. J Immunotoxicol, 6: 249-256, 2009.
4. Pei, Z., Li, H., Guo, Y., Jin, Y., and Lin, D. Sodium selenite inhibits the expression of VEGF, TGFbeta(1) and IL-6 induced by LPS in human PC3 cells via TLR4-NF-(K)B signaling blockage. Int Immunopharmacol, 10: 50-56.
5. Olea-Herrero, N., Vara, D., Malagarie-Cazenave, S., and Diaz-Laviada, I. The cannabinoid R(+)methanandamide induces IL-6 secretion by prostate cancer PC3 cells. J Immunotoxicol, 2009.
6. Chen, J., Xia, D., Luo, J. D., and Wang, P. Exogenous p27KIP1 expression induces anti-tumour effects and inhibits the EGFR/PI3K/Akt signalling pathway in PC3 cells. Asian J Androl, 11: 669-677, 2009.