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> 1-Naphthaleneacetic acid [86-87-3]

1-Naphthaleneacetic acid [86-87-3]

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1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM.

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1-Naphthaleneacetic acid Estructura química

1-Naphthaleneacetic acid Estructura química

No. CAS : 86-87-3

This product is a controlled substance and not for sale in your territory.

Based on 1 publication(s) in Google Scholar

Other Forms of 1-Naphthaleneacetic acid:

  • 1-Naphthaleneacetic acid potassium salt In-stock

Ver todos los productos específicos de isoformas Phospholipase:

Ver todas las isoformas

Descripciòn

1-Naphthaleneacetic acid (1-Naphthylacetic acid), a auxin, can promote plant growth. 1-Naphthaleneacetic acid is also an inhibitor of PLA2, with an IC50 of 13.16 μM[1][2].

IC50 & Target[1]

PLA2

13.16 μM (IC50)

In Vitro

1-Naphthaleneacetic acid (0.7-14 μM) inhibits the activity of PLA2, with the Ki and IC50 of 6.87 μM and 13.16 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1-Naphthaleneacetic acid Related Antibodies
Peso molecular

186.21

Fòrmula

C12H10O2
No. CAS

86-87-3
Appearance

Solid

Color

White to off-white

SMILES

OC(CC1=CC=CC2=C1C=CC=C2)=O
Structure Classification
  • Ketones, Aldehydes, Acids
Initial Source
  • Plants
  • Solanaceae
  • Nicotiana tabacum L.
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvente y solubilidad
In Vitro: 

Methanol : 125 mg/mL (671.29 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (537.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.3703 mL 26.8514 mL 53.7028 mL
5 mM 1.0741 mL 5.3703 mL 10.7406 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (13.43 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (13.43 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación

Purity: 99.89%

COA (251 KB) LCMS (129 KB)

Instrucciones de manejo (2659 KB)
Referencias

  • [1]. Dileep KV, et, al. Crystal structure of phospholipase A 2 in complex with 1-naphthaleneacetic acid. IUBMB Life. 2018 Oct;70(10):995-1001.  [Content Brief]

    [2]. Gómez DA, et al. Effect of 1-naphthaleneacetic acid on organic acid exudation by the roots of white lupin plants grown under phosphorus-deficient conditions. J Plant Physiol. 2014 Sep 15;171(15):1354-61.  [Content Brief]

  • [1]. Dileep KV, et, al. Crystal structure of phospholipase A 2 in complex with 1-naphthaleneacetic acid. IUBMB Life. 2018 Oct;70(10):995-1001.

    [2]. Gómez DA, et al. Effect of 1-naphthaleneacetic acid on organic acid exudation by the roots of white lupin plants grown under phosphorus-deficient conditions. J Plant Physiol. 2014 Sep 15;171(15):1354-61.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / Methanol 1 mM 5.3703 mL 26.8514 mL 53.7028 mL 134.2570 mL
5 mM 1.0741 mL 5.3703 mL 10.7406 mL 26.8514 mL
10 mM 0.5370 mL 2.6851 mL 5.3703 mL 13.4257 mL
15 mM 0.3580 mL 1.7901 mL 3.5802 mL 8.9505 mL
20 mM 0.2685 mL 1.3426 mL 2.6851 mL 6.7129 mL
25 mM 0.2148 mL 1.0741 mL 2.1481 mL 5.3703 mL
30 mM 0.1790 mL 0.8950 mL 1.7901 mL 4.4752 mL
40 mM 0.1343 mL 0.6713 mL 1.3426 mL 3.3564 mL
50 mM 0.1074 mL 0.5370 mL 1.0741 mL 2.6851 mL
60 mM 0.0895 mL 0.4475 mL 0.8950 mL 2.2376 mL
80 mM 0.0671 mL 0.3356 mL 0.6713 mL 1.6782 mL
100 mM 0.0537 mL 0.2685 mL 0.5370 mL 1.3426 mL
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1-Naphthaleneacetic acid Related Classifications

  • Biochemical Assay Reagents
  • Metabolic Enzyme/Protease
  • Phospholipase
Help & FAQs

Keywords:

1-Naphthaleneacetic acid86-87-31-Naphthylacetic acidPhospholipaseauxinplantgrowthPLA2Inhibitorinhibitorinhibit

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