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> Alkyne Cholesterol [1631985-09-5]

Alkyne Cholesterol [1631985-09-5]

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Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an alkyne group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization.

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Alkyne Cholesterol Estructura química

Alkyne Cholesterol Estructura química

No. CAS : 1631985-09-5

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Based on 1 publication(s) in Google Scholar

Descripciòn

Alkyne Cholesterol, a modified lipid, is a click chemistry reagent containing an alkyne group. The terminal alkyne group can be used in a highly specific linking reaction with azide-containing reagents in the presence of a copper (Cu)-containing catalyst. Alkyne Cholesterol can be used for tracking cellular cholesterol metabolism and localization[1][2][3].

Peso molecular

368.60

Fòrmula

C26H40O
No. CAS

1631985-09-5
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2(22)[C@H](C)CCCC#C)(22)[C@@]3(22)[C@@](CC1)(22)[C@@]4(C(C[C@H](CC4)O)=CC3)C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvente y solubilidad
In Vitro: 

DMSO : 4 mg/mL (10.85 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7130 mL 13.5648 mL 27.1297 mL
5 mM 0.5426 mL 2.7130 mL 5.4259 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: ≥95.0%

COA (247 KB) HNMR (104 KB)

Instrucciones de manejo (2659 KB)
Referencias

  • [1]. Katherine Windsor, et al. Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome. J Lipid Res. 2013 Oct;54(10):2842-50.  [Content Brief]

    [2]. Katherine Windsor, et al. Assay of protein and peptide adducts of cholesterol ozonolysis products by hydrophobic and click enrichment methods. Chem Res Toxicol. 2014 Oct 20;27(10):1757-68.  [Content Brief]

    [3]. Alkyne Cholesterol.

  • [1]. Katherine Windsor, et al. Probing lipid-protein adduction with alkynyl surrogates: application to Smith-Lemli-Opitz syndrome. J Lipid Res. 2013 Oct;54(10):2842-50.

    [2]. Katherine Windsor, et al. Assay of protein and peptide adducts of cholesterol ozonolysis products by hydrophobic and click enrichment methods. Chem Res Toxicol. 2014 Oct 20;27(10):1757-68.

    [3]. Alkyne Cholesterol.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7130 mL 13.5648 mL 27.1297 mL 67.8242 mL
5 mM 0.5426 mL 2.7130 mL 5.4259 mL 13.5648 mL
10 mM 0.2713 mL 1.3565 mL 2.7130 mL 6.7824 mL
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Alkyne Cholesterol Related Classifications

  • Click Chemistry
  • Alkynes Labeling and Fluorescence Imaging
  • Reactivos de ensayos bioquímicos
  • Drug Delivery
  • Metabolic Disease
  • Metabolic Enzyme/Protease
  • Liposome
Help & FAQs

Keywords:

Alkyne Cholesterol1631985-09-5Liposomeclick chemistryreagentalkynecholesterolmetabolismlocalizationInhibitorinhibitorinhibit