General Info
| Host: | Mouse |
| Applications: | FC |
| Reactivity: | Human |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description: | Mouse monoclonal antibody anti-Neprilysin is suitable for use in Flow Cytometry research applications. |
| Clonality: | Monoclonal |
| Clone ID: | HI10a |
| Conjugation: | APC |
| Isotype: | IgG1k |
| Formulation: | PBS with 0.05% Proclin300, 1% BSA |
| Storage Instruction: | Recommend storing between 2-8°C and protecting from prolonged exposure to light. Do not freeze this product. |
Information
Description
| Post Translational Modifications | Myristoylation is a determinant of membrane targeting. Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity. |
| Function | Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Catalyzes cleavage of bradykinin, substance P and neurotensin peptides. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers. |
| Protein Name | NeprilysinAtriopeptidaseCommon Acute Lymphocytic Leukemia AntigenCallaEnkephalinaseNeutral Endopeptidase 24.11NepNeutral EndopeptidaseSkin Fibroblast ElastaseSfeCd Antigen Cd10 |
| Database Links | Reactome: R-HSA-2022377Reactome: R-HSA-5578768Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Neprilysin antibodyAnti-Atriopeptidase antibodyAnti-Common Acute Lymphocytic Leukemia Antigen antibodyAnti-Calla antibodyAnti-Enkephalinase antibodyAnti-Neutral Endopeptidase 24.11 antibodyAnti-Nep antibodyAnti-Neutral Endopeptidase antibodyAnti-Skin Fibroblast Elastase antibodyAnti-Sfe antibodyAnti-Cd Antigen Cd10 antibodyAnti-MME antibodyAnti-EPN antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance