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Anti-Navbeta4 Na+ Channel Antibody FL650 Conjugate

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Referencia 75-198-FL650

embalaje : 200uL

Contact local distributor :

Teléfono : +1 850 650 7790

Marca : Antibodies Incorporated

Contact local distributor :

Teléfono : +1 850 650 7790

Our Anti-Navbeta4 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N168/6. It detects mouse and rat Navbeta4 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

550

594

Data Sheet

SKU: 75-198-FL650

Product Details

Target

Navbeta4 Na+ channel

Target Description

Sodium channel subunit beta-4 or Navbeta4 Na+ channel is encoded by SCN4B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß4 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß4 is expressed in many tissues, including the brain (dorsal root ganglia), spinal cord, heart, and skeletal muscle. Defects in this gene are a cause of long QT syndrome type 10 and Familial Atrial Fibrillation.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N168/6

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Scn4b

Molecular Weight

25 kDa

Antigen

Fusion protein amino acids 184-228 (cytoplasmic C-terminus) of rat Navbeta4 (accession number Q7M730) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2939735

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Sodium channel subunit beta-4

UniProt Details

UniProt (Human): Q8IWT1
UniProt (Immunogen Species): Q7M730

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