• SKU DIA-PD1-OD
    Specificity

    PD-1

    Species Reactivity

    Human

    Host Species

    Mouse

    Isotype

    IgG2b

    Clone

    JAD1

    Clonality (Mono-/Polyclonal)

    monoclonal

    Application

    ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)

    Conjugation

    unconjugated

    Dilution

    Immunohistochemistry (IHC): 1:100 – 1:400

    Format

    < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody

    Product line / Topic

    Immuno-Oncology, Tumor Marker / Biology

    Intended Use

    for In vitro Diagnostic Use

    Temperature - Storage

    2-8°C

    Temperature - Transport

    cooled

    Search Code

    CD279, PD-1, PD1, DIAPD1, IHC, FFPE, Paraffin

    Manufacturer / Brand

    dianova

    Uniprot_ID

    Q15116

    Gene_ID

    5133

    Alias

    CD279, HPD1P, PD-1, PDCD1, Programmed Cell Death Protein 1, SLEB2

  • PD-1 (Programmed Cell-Death 1) is expressed by germinal center-associated T cells in reactive lymphoid tissue. PD-1 (CD279, PDCD1, SLEB2) plays a key role in peripheral tolerance and autoimmune disease. Several tumors express ligand for PD1 (PDL1). On binding activated T cells in the tumor microenvironment, PD-1 inactivates antigen specific T cells that would other-wise attack tumor cells. Monoclonal antibodies to PD1 and PDL1 are currently being investigated in clinical trials for their potential to inhibit this pathway with the effect of elevated tumor immunity. Moreover, antibodies directed to PD-1 are also used for di-agnosing certain T-cell derived lymphomas.