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SKU DIA-PD1-OD Specificity PD-1
Species Reactivity Human
Host Species Mouse
Isotype IgG2b
Clone JAD1
Clonality (Mono-/Polyclonal) monoclonal
Application ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections)
Conjugation unconjugated
Dilution Immunohistochemistry (IHC): 1:100 – 1:400
Format < 0.1% NaN3, 1% BSA, concentrate, in Tris buffer (pH 7.3-7.7), ProteinA/G purified antibody
Product line / Topic Immuno-Oncology, Tumor Marker / Biology
Intended Use for In vitro Diagnostic Use
Temperature - Storage 2-8°C
Temperature - Transport cooled
Search Code CD279, PD-1, PD1, DIAPD1, IHC, FFPE, Paraffin
Manufacturer / Brand dianova
Uniprot_ID Q15116
Gene_ID 5133
Alias CD279, HPD1P, PD-1, PDCD1, Programmed Cell Death Protein 1, SLEB2
- PD-1 (Programmed Cell-Death 1) is expressed by germinal center-associated T cells in reactive lymphoid tissue. PD-1 (CD279, PDCD1, SLEB2) plays a key role in peripheral tolerance and autoimmune disease. Several tumors express ligand for PD1 (PDL1). On binding activated T cells in the tumor microenvironment, PD-1 inactivates antigen specific T cells that would other-wise attack tumor cells. Monoclonal antibodies to PD1 and PDL1 are currently being investigated in clinical trials for their potential to inhibit this pathway with the effect of elevated tumor immunity. Moreover, antibodies directed to PD-1 are also used for di-agnosing certain T-cell derived lymphomas.
Anti-PD-1 (Hu) from Mouse (JAD1)
Referencia DIA-PD1-OD
embalaje : 100µl
Marca : Dianova
Para uso de diagnóstico in vitro. Sólo para uso profesional.