General Info
| Host: | Rabbit |
| Applications: | CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: | Chicken/Human/Monkey/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PDE3B (1060-1110) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.70 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:200IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | Pde3b |
| Gene ID: | 29516 |
| Uniprot ID: | PDE3B_RAT |
| Immunogen Region: | 1060-1110 |
| Specificity: | Does not cross react with PDE4A variants nor with any other PDE famly members. This antibody will recognize PDE3B variants. |
| Immunogen: | Synthetic peptide taken within amino acid region 1060-1110 on human PDE3B protein. |
Description
| Tissue Specificity | Abundant in adipose tissues. |
| Post Translational Modifications | Phosphorylation at Ser-279 mediates insulin-induced activation of PDE3B. |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes. |
| Protein Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3bCgi PdeCyclic Gmp-Inhibited Phosphodiesterase BCgi-Pde BRcgipl |
| Database Links | Reactome: R-RNO-165160Reactome: -RNO-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b antibodyAnti-Cgi Pde antibodyAnti-Cyclic Gmp-Inhibited Phosphodiesterase B antibodyAnti-Cgi-Pde B antibodyAnti-Rcgipl antibodyAnti-Pde3b antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance