Anti-S100 Antibody
Referencia OAAI00287
embalaje : 100ug
Marca : Aviva Systems Biology
Contact local distributor :
Teléfono : +1 850 650 7790
Anti-S100 Antibody (OAAI00287)
| Datasheets/Manuals | Printable datasheet for Anti-S100 Antibody (OAAI00287) |
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| Predicted Species Reactivity | Human|Mouse|Rat |
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| Product Format | Liquid. This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer |
| Clonality | Monoclonal |
| Clone | 15E2E2 |
| Isotype | IgG1 |
| Host | Mouse |
| Application | ELISA, FC, IHC, IP, WB |
| Additional Information | Background: S100 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100α and β, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin α and parvalbumin β, also designated oncomodulin (OCM). S100 may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. |
| :: | Positive Control: Melanoma or Schwannoma |
| :: | Cellular Location: Cytoplasmic |
| Reconstitution and Storage | The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles. |
| Immunogen | Purified bovine brain S100 protein. |
| Purification | The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping |
| Concentration | 100ug/200ul |
| Specificity | S100A1 |
| Formulation | This affinity purified antibody is supplied in sterile Phosphatebuffered saline (pH7.2) containing antibody stabilizer |
| Application Info | WB: 0.1-1 ug/ml | ELISA: 0.01-0.1 ug/ml | IP: 2-5 ug/ml | IHC: 2-10 ug/ml | FC: Not tested |
