General Info
Host: | Rabbit |
Applications: | WB/IF |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-SYT12 (95-200) is suitable for use in Western Blot and Immunofluorescence research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000IF/ICC 1:50-1:200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | SYT12 |
Gene ID: | 91683 |
Uniprot ID: | SYT12_HUMAN |
Immunogen Region: | 95-200 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 95-200 of human SYT12 (NP_001171351.1). |
Immunogen Sequence: | KGSLSIEDTFESISELGPLE LMGRELDLAPYGTLRKSQSA DSLNSISSVSNTFGQDFTLG QVEVSMEYDTASHTLNVAVM QGKDLLEREEASFESCFMRV SLLPDE |
Description
Post Translational Modifications | Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation. |
Function | Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release. Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids. Essential for mossy-fiber long-term potentiation in the hippocampus. |
Protein Name | Synaptotagmin-12Synaptotagmin XiiSytxii |
Database Links | Reactome: R-HSA-6794361 |
Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Membrane Protein |
Alternative Antibody Names | Anti-Synaptotagmin-12 antibodyAnti-Synaptotagmin Xii antibodyAnti-Sytxii antibodyAnti-SYT12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance