BCoR (C-10)
Referencia sc-514576
embalaje : 200µg/ml
Marca : Santa Cruz Biotechnology
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Anticorps BCoR (C-10): sc-514576
- L'anticorps BCoR C-10 est un monoclonal IgG1 κ L'Anticorps BCoR, cité dans 32 publications, fourni en 200 µg/ml
- dirigé contre les acides aminés 1-300 situés au niveau N-terminus de BCoR d'origine human
- L'Anticorps BCoR (C-10) est recommandé pour la détection de BCoR d'origine human par WB, IP, IF et ELISA
- Anti-L'Anticorps BCoR (C-10) est disponible conjugué à l'agarose pour IP; à l'HRP pour WB, IHC(P) et ELISA; et soit à la phycoerythrin ou FITC pour IF, IHC(P) et FCM
- aussi disponible conjugué à l'Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 ou Alexa Fluor® 647 pour WB (RGB), IF, IHC(P) et FCM
- aussi disponible conjugué à l'Alexa Fluor® 680 ou Alexa Fluor® 790 pour WB (NIR), IF et FCM
- m-IgG Fc BP-HRP et m-IgGκ BP-HRP sont les réactifs secondaires recommandés pour la détection de l'anticorps BCoR (C-10) pour des applications de WB. Ces réactifs sont maintenant proposés en kit avec l'anticorps BCoR (C-10) ().
ACCÈS RAPIDE AUX LIENS
and Cruz Marker™ MW Standards Promotional
BCoR Antibody (C-10) is an IgG1 κ mouse monoclonal BCoR antibody (also designated BCoR antibody) that detects the BCoR protein of human origin by WB, IP, IF and ELISA. BCoR Antibody (C-10) is available as both the non-conjugated anti-BCoR antibody form, as well as multiple conjugated forms of anti-BCoR antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFκB expression, thereby inhibiting NFκB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin′s lymphoma. BCoR (BCL-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its 3 ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
References:
- BCoR, a novel corepressor involved in BCL-6 repression. | Huynh, KD., et al. 2000. Genes Dev. 14: 1810-23. PMID: 10898795
- Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR. | Ng, D., et al. 2004. Nat Genet. 36: 411-6. PMID: 15004558
- Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. | Gearhart, MD., et al. 2006. Mol Cell Biol. 26: 6880-9. PMID: 16943429
- A two base pair deletion in the PQBP1 gene is associated with microphthalmia, microcephaly, and mental retardation. | Martínez-Garay, I., et al. 2007. Eur J Hum Genet. 15: 29-34. PMID: 17033686
- Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor. | Sánchez, C., et al. 2007. Mol Cell Proteomics. 6: 820-34. PMID: 17296600
- Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer. | Ghetu, AF., et al. 2008. Mol Cell. 29: 384-91. PMID: 18280243
- Role of the transcriptional corepressor Bcor in embryonic stem cell differentiation and early embryonic development. | Wamstad, JA., et al. 2008. PLoS One. 3: e2814. PMID: 18795143
Espèces | Nom du Gène | Gene ID | Localisation chromosomique | Numéro d'accession de l'isoforme (ARNm) | Numéro d'accès aux protéines | Numéro OMIM™ |
---|---|---|---|---|---|---|
Human | BCOR | Entrez Gene ID: 54880 | Xp11.4 | XM_005272616, XM_005272618, XM_005272619, XM_005272620, XM_006724536, XM_011543929, XM_011543930, XM_011543931, XM_017029615, XM_017029616, NM_001123383, NM_001123384, NM_001123385, NM_017745, NM_001130139, NM_020926 | UniProt ID: Q6W2J9 | 300485 |
Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz® conjugates which eliminates the need for a secondary antibody.
Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BCoR Antibody (C-10) has 32 citations in a variety of scientific publications.
Primary antibodies like Anti-BCoR Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps BCoR (C-10) | sc-514576 | 200 µg/ml | .00 | |||
BCoR (C-10): m-IgG Fc BP-HRP Kit | sc-531167 | 200 µg Ab; 10 µg BP | .00 | |||
BCoR (C-10): m-IgGκ BP-HRP Kit | sc-524777 | 200 µg Ab, 40 µg BP | .00 | |||
Anticorps BCoR (C-10) AC | sc-514576 AC | 500 µg/ml, 25% agarose | .00 | |||
Anticorps BCoR (C-10) HRP | sc-514576 HRP | 200 µg/ml | .00 | |||
Anticorps BCoR (C-10) FITC | sc-514576 FITC | 200 µg/ml | .00 | |||
Anticorps BCoR (C-10) PE | sc-514576 PE | 200 µg/ml | .00 | |||
Anticorps BCoR (C-10) Alexa Fluor® 488 | sc-514576 AF488 | 200 µg/ml | .00 | |||
Anticorps BCoR (C-10) Alexa Fluor® 546 | sc-514576 AF546 | 200 µg/ml | .00 | |||
Anticorps BCoR (C-10) Alexa Fluor® 594 | sc-514576 AF594 | 200 µg/ml | .00 | |||
Anticorps BCoR (C-10) Alexa Fluor® 647 | sc-514576 AF647 | 200 µg/ml | .00 | |||
Anticorps BCoR (C-10) Alexa Fluor® 680 | sc-514576 AF680 | 200 µg/ml | .00 | |||
Anticorps BCoR (C-10) Alexa Fluor® 790 | sc-514576 AF790 | 200 µg/ml | .00 |
Hi, We are having an issue validating the lot of BCOR SC-514576 E1623 for immunohistochemistry on formalin fixed paraffin embeded tissue. We have used the previous lot E2616 with no issues. Has there been any issues reported with this lot. Thanks
Does BCoR Antibody (C-10) been tested for detecting mouse BCOR protein ? It is unclear from the description on website as references (not citations!) stated on the santacruz website indicate ref 1,7 are mouse bcor protein and not human origin
i have order BCOR C-10 HRP FOR USE IN PARAFFINE EMBEDDED BLOCK ...USED TESTIS SECTIONS AS CONTROL BUT IS NOT GIVING RESULT....TRIED AT DILUTION 1.50,1:100,1:150 AT PH 6 ... KINDLY HELP ME OUT WHAT TO DO??????? I AM A P.G STUDENT
Kindly let us know the BCOR Aantibody (C-10) clone for use by IMMUNOHISTOCHEMISTRY NOT western blotting asap. Thanks.
Can BCoR Antibody (C-10): sc-514576 be used for detection of DOCK 8 in samples other than human?
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