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> BODIPY FL prazosin [175799-93-6]

BODIPY FL prazosin [175799-93-6]

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BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes.

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BODIPY FL prazosin Estructura química

BODIPY FL prazosin Estructura química

No. CAS : 175799-93-6

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Based on 1 publication(s) in Google Scholar

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α adrenergic receptor β adrenergic receptor
Descripciòn

BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes[1][2][3].

IC50 & Target[1]

α1A-adrenergic receptor

14.5 nM (Ki)

α1B-adrenergic receptor

43.3 nM (Ki)

In Vitro

BODIPY FL prazosin (10 nM; 30 min at room temperature in 100 μl; COS-7 cells) shows Affinity of various α1-AR ligands with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively[1].
BODIPY FL prazosin (100 nM, 30 min) can be used as molecular probe for the Visualization of the non-adrenoceptor binding site of α1-adrenergic drugs in erythroleukemia cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BODIPY FL prazosin Related Antibodies
Peso molecular

563.41

Fòrmula

C28H32BF2N7O3
No. CAS

175799-93-6
Emission (Em)

510
Excitation (Ex)

502
SMILES

O=C(CCC1=CC=C2C=C3C(C)=CC(C)=23[B+3]([F-])([N-]21)[F-])N4CCN(CC4)C5=NC6=C(C=C(C(OC)=C6)OC)C(N)=N5
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias

  • [1]. Sugawara T, et al. Differences in the subcellular localization of alpha1-adrenoceptor subtypes can affect the subtype selectivity of drugs in a study with the fluorescent ligand BODIPY FL-prazosin. Life Sci. 2002 Mar 22;70(18):2113-24.  [Content Brief]

    [2]. Cerveny L, et al. Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents. Epilepsia. 2006 Mar;47(3):461-8.  [Content Brief]

    [3]. Fuchs R, et al. α1-adrenergic drugs exhibit affinity to a thapsigargin-sensitive binding site and interfere with the intracellular Ca2+ homeostasis in human erythroleukemia cells. Exp Cell Res. 2011 Dec 10;317(20):2969-80.  [Content Brief]

  • [1]. Sugawara T, et al. Differences in the subcellular localization of alpha1-adrenoceptor subtypes can affect the subtype selectivity of drugs in a study with the fluorescent ligand BODIPY FL-prazosin. Life Sci. 2002 Mar 22;70(18):2113-24.

    [2]. Cerveny L, et al. Lack of interactions between breast cancer resistance protein (bcrp/abcg2) and selected antiepileptic agents. Epilepsia. 2006 Mar;47(3):461-8.

    [3]. Fuchs R, et al. α1-adrenergic drugs exhibit affinity to a thapsigargin-sensitive binding site and interfere with the intracellular Ca2+ homeostasis in human erythroleukemia cells. Exp Cell Res. 2011 Dec 10;317(20):2969-80.

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BODIPY FL prazosin Related Classifications

  • Metabolic Disease
  • GPCR/G Protein Neuronal Signaling
  • Adrenergic Receptor

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BODIPY FL prazosin175799-93-6Adrenergic ReceptorBeta ReceptorCOS-7 cellsα1a-ARα1b-ARMEF3.8-BCRP cellsmolecular probeerythroleukemia cellsInhibitorinhibitorinhibit