CD49b (ITGA2) mouse monoclonal antibody, clone AK7, PE
Specifications
Product Data
Clone Name
AK7
Application
FC
Recommended Dilution
Flow Cytometry: Use 10 µl of neat CD49b antibody to label 10e6 cells or 100 µl human whole blood.
Reactivity
Human, Monkey
Antibody Host
Mouse
Isotype
IgG1
Clonality
Monoclonal
Specificity
Recognizes the Integrin alpha 2 subunit (CD49b), which is a 160kD glycoprotein that non-covalently associates with the 130kD integrin beta1 subunit to form the VLA-2 complex.
Buffer
PBS, pH 7.2 with 0.09% Sodium Azide as preservative, 1% BSA and 5% Sucrose. Label: PE State: Lyophilized purified IgG fraction Label: R. Phycoerythrin (RPE)
Reconstitution Method
Restore with 1.0 ml distilled water.
Purification
Affinity Chromatography on Protein G
Conjugation
PE
Storage
Prior to and Following reconstitution store the antibody undiluted at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. CD49b is a 160kD glycoprotein that non-covalently associates with the 130kD integrin beta 1 subunit to form the VLA-2 complex. CD49b is expressed by platelets, long term cultivated T cells, approximately 50% of monocytes and most adherent cell lines.
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
