Our DUSP22/IRF4 break apart probe is designed to detect rearrangements in the 6p25 region containing both DUSP22 and IRF4. The probe comes labeled in orange and green, but can be customized to meet your needs. 

Gene Background: DUSP22 is a member of the Dual Specificity Phosphatase family, a subset of proteins that are expressed in nearly all mammalian cell types.¹ DUSP22’s effector proteins include the estrogen receptor ER⍺, a breast cancer regulator and IL6, a leukemia inhibitor.² IRF4 lies adjacent to DUSP22, and encodes Interferon Regulatory Factor 4, a protein that aids in normal B lymphocyte development and inhibits BCR/ABL transformation of myeloid cells, both of which are crucial in preventing hematopoietic malignancies.^3,4 DUSP22-IRF4 break-apart rearrangements were the first type of recurrent translocation identified in ALK-negative Anaplastic Large Cell Lymphoma (ALCL), and recent research reports that DUSP22-IRF4 translocations occur in 20-57% of primary cutaneous ALCLCs.⁵  Therefore, DUSP22-IRF4 breaks are likely to disrupt important cancer-suppressing mechanisms in the 6p25 region where both genes reside.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.