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Fluconazole hydrate [155347-36-7]

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Referencia B1226-5g

embalaje : 5g

Contact local distributor :

Teléfono : +1 850 650 7790

Marca : APExBIO Technology

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Contact local distributor :

Teléfono : +1 850 650 7790

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Background

Fluconazole (hydrate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.

Chemical Properties

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	324.29
Cas No.	155347-36-7
Formula	C₁₃H₁₄F₂N₆O₂
Solubility	≥16.35 mg/mL in DMSO; ≥28.8 mg/mL in EtOH; ≥3.2 mg/mL in H2O with ultrasonic
Chemical Name	2-(2,4-difluorophenyl)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol hydrate
SDF	Download SDF
Canonical SMILES	FC1=CC(F)=C(C(CN2C=NC=N2)(O)CN3C=NC=N3)C=C1.O
Shipping Condition	Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips	We do not recommend long-term storage for the solution, please use it up soon.

Protocol

Cell experiment [1]:
Cell lines	Pathogenic Candida species
Preparation method	The solubility of this compound in DMSO is ≥16.35mg/mL. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.
Reacting condition	100 mg/l
Applications	In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/1. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10−6 M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this.
References: [1]. Odds FC, Cheesman SL, Abbott AB. Antifungal effects of fluconazole (UK 49858), a new triazole antifungal, in vitro. J Antimicrob Chemother. 1986 Oct;18(4):473-8. PubMed PMID: 3021710.

Quality Control

Purity = 99.17%

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